Leboulleux Sophie, Hartl Dana, Baudin Eric, Schlumberger Martin
Institut Gustave-Roussy, université Paris-Sud, service de médecine nucléaire et de cancérologie endocrinienne, Villejuif, France.
Bull Cancer. 2012 Nov;99(11):1093-9. doi: 10.1684/bdc.2012.1645.
Thyroid carcinoma is a rare disease in children, and is mostly of the papillary histological type. Lymph node metastases are frequent at diagnosis, being present in 23 to 74% of the cases and can reveal the cancer in about one fourth of cases. Lung metastases are present at initial diagnosis in 6 to 20% of cases. The main known risk factor for thyroid cancer is a previous history of radiation exposure. Treatment includes surgery with total thyroidectomy and lymph node dissection and radioiodine therapy in case of extensive disease and distant metastases. Life-long thyroxine treatment is given to all patients. Long term prognosis is favourable, but thyroid cancer related deaths have been reported some decades after initial treatment.
甲状腺癌在儿童中是一种罕见疾病,且大多为乳头状组织学类型。诊断时淋巴结转移很常见,23%至74%的病例存在淋巴结转移,约四分之一的病例可通过淋巴结转移发现癌症。6%至20%的病例在初次诊断时已有肺转移。已知甲状腺癌的主要危险因素是既往有辐射暴露史。治疗包括手术,即全甲状腺切除术和淋巴结清扫术,对于疾病广泛和有远处转移的病例则进行放射性碘治疗。所有患者均给予终身甲状腺素治疗。长期预后良好,但有报道称在初始治疗数十年后出现了与甲状腺癌相关的死亡。