Alpan G, Clyman R I
Cardiovascular Research Institute, University of California, San Francisco 94143.
Pediatr Res. 1990 Feb;27(2):133-6. doi: 10.1203/00006450-199002000-00006.
Methylprednisolone (30 mg/kg), which inhibits a number of mediators of hypoxic pulmonary vasoconstriction derived from arachidonic acid, has been found to alleviate hypoxic pulmonary vasoconstriction in adult humans and in the isolated rat lung preparation. We studied the effect of 30 mg/kg of methylprednisolone on the pulmonary vascular response to hypoxia in six late-gestation newborn lambs. During hypoxia, pulmonary vascular resistance nearly doubled compared with the baseline hyperoxic state. This was true both before and after administration of methylprednisolone. We conclude that methylprednisolone, when administered at the dosage used in previous studies of adult humans and animals, does not affect the response of the pulmonary vascular bed to hypoxia in newborn lambs.
甲泼尼龙（30毫克/千克）可抑制多种源自花生四烯酸的低氧性肺血管收缩介质，已发现其可缓解成年人类和离体大鼠肺标本中的低氧性肺血管收缩。我们研究了30毫克/千克甲泼尼龙对6只妊娠晚期新生羔羊肺血管对低氧反应的影响。在低氧期间，与基线高氧状态相比，肺血管阻力几乎增加了一倍。在给予甲泼尼龙之前和之后都是如此。我们得出结论，以先前在成年人类和动物研究中使用的剂量给予甲泼尼龙，不会影响新生羔羊肺血管床对低氧的反应。
