Strømme-Hansen L, Bjertnaes L J, Vaage J
Acta Anaesthesiol Scand. 1985 May;29(4):446-52. doi: 10.1111/j.1399-6576.1985.tb02231.x.
The effect of pharmacological doses of methylprednisolone (MP) on the pulmonary vasoconstrictor response to hypoxia has been investigated in two groups of isolated rat lung preparations, one consisting of ventilated, and the other of atelectatic lungs. In both groups, MP reduced the vasoconstrictor response to hypoxia in a dose-dependent fashion. At a perfusate concentration of 3 mmol/l of MP, the response was reduced by about 80%. On the contrary, the vasoconstrictor response to injections of standardized doses of angiotensin II, used as an independent vasoconstrictor substance, were not significantly changed by MP, even when administered at a concentration which completely abolished the response to hypoxia. We suggest that MP inhibits the pulmonary vasoconstrictor response to hypoxia without influencing the general reactivity of the pulmonary vascular bed.
在两组离体大鼠肺标本中研究了药理剂量的甲基强的松龙（MP）对低氧性肺血管收缩反应的影响，一组为通气肺，另一组为肺不张肺。在两组中，MP均以剂量依赖性方式降低了对低氧的血管收缩反应。当灌注液中MP浓度为3 mmol/l时，反应降低了约80%。相反，作为独立血管收缩物质的标准化剂量血管紧张素II注射所引起的血管收缩反应，即使在以完全消除对低氧反应的浓度给药时，也未被MP显著改变。我们认为，MP抑制了对低氧的肺血管收缩反应，而不影响肺血管床的一般反应性。
