通过结合竞争（RABC）评估耐药性的化学探针：奥司他韦敏感性评估。
Chemical probes for drug-resistance assessment by binding competition (RABC): oseltamivir susceptibility evaluation.
机构信息
The Genomics Research Center, Academia Sinica, Taipei, Taiwan.
出版信息
Angew Chem Int Ed Engl. 2013 Jan 2;52(1):366-70. doi: 10.1002/anie.201204062. Epub 2012 Nov 13.
PMID:23150231
Abstract
The wizard of OS (resistance): the binding difference of neuraminidase inhibitors (zanamivir versus oseltamivir (OS)) was used to establish an assay to identify the influenza subtypes that are resistant to OS but still sensitive to zanamivir. This assay used a zanamivir-biotin conjugate to determine the OS susceptibility of a wide range of influenza viruses and over 200 clinical isolates.
摘要
OS（耐药性）的巫师：神经氨酸酶抑制剂（扎那米韦与奥司他韦（OS））的结合差异被用于建立一种测定方法，以鉴定对 OS 耐药但对扎那米韦仍敏感的流感病毒亚型。该测定方法使用了一种扎那米韦-生物素缀合物来确定各种流感病毒和 200 多个临床分离株对 OS 的敏感性。
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