双硫仑及其主要代谢产物在红细胞细胞膜上的分布以及红细胞醛脱氢酶活性的失活
Distribution of disulfiram and its chief metabolites over erythrocyte cell membranes and inactivation of erythrocyte aldehyde dehydrogenase activity.
作者信息
Johansson B
机构信息
Department of Clinical Chemistry, General Hospital, Malmö, Sweden.
出版信息
Pharmacol Toxicol. 1990 Feb;66(2):104-8. doi: 10.1111/j.1600-0773.1990.tb00714.x.
The distribution of disulfiram (Antabuse over erythrocyte cell membranes and the inhibitory action of the parent drug and its metabolites on a disulfiram sensitive erythrocyte isozyme of aldehyde dehydrogenase (ALDH) was investigated in intact and haemolyzed human erythrocytes. These studies showed that not only disulfiram but also its bis(diethyldithiocarbamato) copper complex (Cu(DDC)2) were distributed over the erythrocyte cell membranes. In addition, disulfiram was the only substance examined that inactivaed erythrocyte ALDH, a reaction which was dependent on the concentration of disulfiram added.
在完整和溶血的人红细胞中，研究了双硫仑（戒酒硫）在红细胞膜上的分布以及母体药物及其代谢产物对双硫仑敏感的醛脱氢酶（ALDH）红细胞同工酶的抑制作用。这些研究表明，不仅双硫仑，而且其双（二乙基二硫代氨基甲酸）铜络合物（Cu(DDC)2）也分布在红细胞膜上。此外，双硫仑是所检测的唯一能使红细胞ALDH失活的物质，该反应取决于所添加双硫仑的浓度。
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