使用多级正交/同时动态组合文库对受体进行两阶段扩增。
Two-stage amplification of receptors using a multilevel orthogonal/simultaneous dynamic combinatorial library.
机构信息
Farmacognosia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina.
出版信息
Org Lett. 2012 Dec 7;14(23):5816-9. doi: 10.1021/ol3027335. Epub 2012 Nov 15.
PMID:23153248
Abstract
Sequential activation of different reversible exchange reactions in a dynamic combinatorial library allows directed exploration of the chemical space: initially a macrocyclic scaffold is selected by the template and finally side chain and conformational constrains are introduced into such a scaffold.
摘要
在动态组合库中，不同可逆交换反应的顺序激活允许对化学空间进行有针对性的探索：首先通过模板选择大环支架，最后将侧链和构象约束引入到这种支架中。
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