BMP 与 AML 的相遇：新型融合基因诱导 BMP 信号转导促进小儿急性白血病。
BMP meets AML: induction of BMP signaling by a novel fusion gene promotes pediatric acute leukemia.
机构信息
Division of Hematology/Oncology, Northwestern University, University of Chicago, Chicago, IL 60637, USA.
出版信息
Cancer Cell. 2012 Nov 13;22(5):567-8. doi: 10.1016/j.ccr.2012.10.008.
Abstract
In this issue of Cancer Cell, Gruber et al. report that a significant proportion of children with acute megakaryoblastic leukemia acquire a translocation that confers enhanced BMP signaling and promotes self-renewal of hematopoietic progenitors. This study presents novel therapeutic targets that may lead to improved therapies for this aggressive leukemia.
摘要
在本期《癌细胞》中，Gruber 等人报告称，相当一部分患有急性巨核细胞白血病的儿童获得了一种易位，该易位赋予了增强的 BMP 信号，并促进了造血祖细胞的自我更新。这项研究提出了新的治疗靶点，可能为这种侵袭性白血病带来更好的治疗方法。
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