Department of Obstetrics and Gynecology, Taizhou Hospital of Zhejiang Province, Wenzhou Medical College, Linhai City, China.
Int J Infect Dis. 2013 Jan;17(1):e54-8. doi: 10.1016/j.ijid.2012.09.002. Epub 2012 Nov 13.
To detect father-to-fetus transmission of hepatitis B virus (HBV) in utero.
We conducted a study at the prenatal diagnosis center of Taizhou City. Fetuses with one or both parents carrying the hepatitis B surface antigen (HBsAg) were identified before genetic testing during the period 2008-2010. Intrauterine samples were obtained by amniocentesis or cordocentesis and tested for serological markers and by quantitative DNA assays. All neonates received combined hepatitis B immunoprophylaxis after delivery, and serological follow-up tests were performed at 1 year of age.
Of the 407 couples enrolled in the study, HBV was carried by fathers only in 164, and none of their fetuses were found to be HBV DNA-positive in utero. All fetal serological markers were found to be of maternal but not paternal origin. The response rate to postnatal vaccination was 98.6%, and none of the children who failed immunoprophylaxis were the offspring of the HBV carrier fathers.
The infection of fetuses with HBV from the spermatozoa of carrier fathers seems unlikely, especially in an area where pre-conception hepatitis B vaccination is routinely provided.
检测乙型肝炎病毒（HBV）在子宫内从父亲向胎儿的传播。
我们在泰州市产前诊断中心进行了一项研究。在 2008 年至 2010 年期间，在进行基因检测之前，确定了携带乙型肝炎表面抗原（HBsAg）的父母一方或双方的胎儿。通过羊膜穿刺术或脐带穿刺术获得宫内样本，并进行血清学标志物检测和定量 DNA 检测。所有新生儿在分娩后均接受乙型肝炎联合免疫预防，在 1 岁时进行血清学随访检测。
在 407 对夫妇中，只有 164 对父亲携带 HBV，他们的胎儿在子宫内均未发现 HBV DNA 阳性。所有胎儿的血清学标志物均来自母亲，而非父亲。对产后疫苗接种的反应率为 98.6%，未进行免疫预防的儿童均非 HBV 携带者父亲的后代。
从携带者父亲的精子感染胎儿 HBV 的可能性似乎不大，特别是在常规提供孕前乙型肝炎疫苗接种的地区。
