TLRs 和 IFNs：自身免疫谜题的关键部分。
TLRs and IFNs: critical pieces of the autoimmunity puzzle.
机构信息
Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, California 92037, USA.
出版信息
J Clin Invest. 2012 Oct;122(10):3464-6. doi: 10.1172/JCI63835. Epub 2012 Oct 1.
Abstract
Discoveries revealing the molecular basis of innate immune responses, particularly the identification of Toll-like receptors (TLRs) as the major recognition sensors for microbial and even self-molecules, have provided new insights into the pathogenesis of both systemic and organ-specific autoimmune diseases. These insights will permit the development of novel treatment modalities for these disorders.
摘要
揭示先天免疫反应分子基础的发现，特别是鉴定 Toll 样受体（TLRs）作为微生物甚至自身分子的主要识别传感器，为系统性和器官特异性自身免疫性疾病的发病机制提供了新的见解。这些见解将为这些疾病的治疗提供新的方法。
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