链球菌血红素蛋白受体：一个兼职蛋白还是一个毒力因子？
The streptococcal hemoprotein receptor: a moonlighting protein or a virulence factor?
出版信息
Virulence. 2012 Nov 15;3(7):553-5. doi: 10.4161/viru.22440.
Abstract
The β-hemolytic group A streptococcus (GAS) is a major pathogen that readily uses hemoglobin to satisfy its requirements for iron. The streptococcal hemoprotein receptor in GAS plays a central role in heme utilization and binds fibronectin and laminin in vitro. Shr inactivation attenuates the virulent M1T1 GAS strain in two murine infection models and reduces bacterial growth in blood and binding to laminin. Shr impact on the globally disseminated M1T1 strain underscores the importance of heme uptake in GAS pathogenesis and raises the possibility of targeting heme-uptake proteins in the development of new methods to combat GAS infections.
摘要
β-溶血性 A 组链球菌（GAS）是一种主要病原体，它可以轻易地利用血红蛋白来满足其对铁的需求。GAS 中的链球菌血红素蛋白受体在血红素利用中起着核心作用，并在体外结合纤维连接蛋白和层粘连蛋白。Shr 失活可减弱两种小鼠感染模型中的毒力 M1T1 GAS 菌株，并减少血液中的细菌生长和与层粘连蛋白的结合。Shr 对全球传播的 M1T1 菌株的影响突显了 GAS 发病机制中血红素摄取的重要性，并提出了在开发新方法来对抗 GAS 感染时靶向血红素摄取蛋白的可能性。
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