Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza - BCM280, Houston, TX 77030, USA.
Metallomics. 2011 Aug;3(8):788-96. doi: 10.1039/c1mt00047k. Epub 2011 Jul 4.
The element iron is essential for bacteria and plays a key role in the virulence and pathology of bacterial diseases. The largest reservoir of iron within the human body is in protoporphyrin IX, the compound commonly referred to as heme and bound by hemoglobin. For many years, the study of heme uptake in bacteria was restricted to Gram-negative organisms. However, recent studies have shed light on how bacteria containing a thick peptidoglycan, such as Gram-positive bacteria, acquire and transport heme. This review summarizes old and new research covering the acquisition, transport, and utilization of heme in Gram-positive bacterial pathogens.
铁元素对细菌来说是必不可少的，它在细菌疾病的毒力和病理学中起着关键作用。人体内铁的最大储存库是原卟啉 IX，通常称为血红素的化合物，并与血红蛋白结合。多年来，细菌中血红素摄取的研究仅限于革兰氏阴性生物。然而，最近的研究揭示了含有厚肽聚糖的细菌（如革兰氏阳性菌）如何获取和运输血红素。这篇综述总结了涵盖革兰氏阳性细菌病原体中血红素获取、运输和利用的旧有和新的研究。
