University of California Davis Medical Center, Department of Radiology, Sacramento, CA, USA.
Anticancer Res. 2012 Nov;32(11):4951-61.
Response Evaluation Criteria in Solid Tumors (RECIST)-defined measurements are limited when evaluating soft tissue sarcoma (STS) response to therapy. Histopathological assessment of STS response requires a determination of necrosis following resection. A novel semi-automated technique for volumetric measurement of tumor necrosis, using enhanced magnetic resonance imaging (CE-MRI), is described.
Eighteen patients with STS were treated with neoadjuvant therapy and then resected. CE-MRI, obtained prior to resection, were evaluated by two observers using semi-automated segmentation. Tumor volume and percent necrosis was compared with histology and RECIST measurements.
The median percent necrosis, determined histologically and from CE-MRI, was 71.9% and 67.8%, respectively. Accuracy of these semi-automated measurements was confirmed, being statistically similar to those obtained at histopathological assessment of the resected tumor. High Intra-class correlation co-efficients suggest good inter-observer reproducibility. Tumor necrosis did not correlate with the RECIST measurements.
Semi-automated determination of tumor volume and necrosis, using CE-MRI, is suggested to be accurate and reproducible.
在评估软组织肉瘤（STS）对治疗的反应时，实体瘤反应评估标准（RECIST）定义的测量值是有限的。STS 反应的组织病理学评估需要确定切除后的坏死。描述了一种用于评估肿瘤坏死的新型半自动化容积测量技术，即增强磁共振成像（CE-MRI）。
18 名 STS 患者接受新辅助治疗，然后进行切除。在切除前获得的 CE-MRI 由两名观察者使用半自动分割进行评估。肿瘤体积和坏死百分比与组织学和 RECIST 测量结果进行了比较。
组织学和 CE-MRI 确定的中位数坏死百分比分别为 71.9%和 67.8%。这些半自动测量的准确性得到了证实，与对切除肿瘤进行组织病理学评估获得的结果具有统计学相似性。高组内相关系数表明观察者之间具有良好的可重复性。肿瘤坏死与 RECIST 测量值无关。
使用 CE-MRI 半自动确定肿瘤体积和坏死百分比被认为是准确和可重复的。
