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低水平激光治疗对嵌合同种异体移植物的影响。

Effect of low-level laser therapy on incorporation of block allografts.

机构信息

School of Dentistry, Universidade do Planalto Catarinense, Lages, Brazil.

出版信息

Int J Med Sci. 2012;9(10):853-61. doi: 10.7150/ijms.4440. Epub 2012 Nov 5.

DOI:10.7150/ijms.4440
PMID:23155359
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3498750/
Abstract

OBJECTIVE

To assess the effect of low-level laser therapy (LLLT) on the incorporation of deep-frozen block allografts in a rabbit model.

BACKGROUND DATA

Studies have shown that LLLT has beneficial effects on tissue repair and new bone formation.

METHODS

Bone tissue was harvested from two rabbits, processed by deep-freezing and grafted into the calvaria of 12 animals, which were then randomly allocated into two groups: experimental (L) and control (C). Rabbits in group L were irradiated with an aluminum gallium arsenide diode laser (AlGaAs; wavelength 830 nm, 4 J/cm(2)), applied to four sites on the calvaria, for a total dose of 16 J/cm(2) per session. The total treatment dose after eight sessions was 128 J/cm(2). Animals were euthanized at 35 (n = 6) or 70 days (n = 6) postoperatively.

RESULTS

Deep-freeze-processed block allografts followed by LLLT showed incorporation at the graft-host interface, moderate bone remodeling, partial filling of osteocyte lacunae, less inflammatory infiltrate in the early postoperative period, and higher collagen deposition than the control group.

CONCLUSION

Optical microscopy and scanning electron microscopy showed that allograft bone processed by deep-freezing plus LLLT is suitable as an alternative for the treatment of bone defects. Use of the deep-freezing method for processing of bone grafts preserves the structural and osteoconductive characteristics of bone tissue.

摘要

目的

评估低水平激光疗法（LLLT）对冷冻块同种异体移植物在兔模型中植入的影响。

背景资料

研究表明，LLLT 对组织修复和新骨形成具有有益作用。

方法

从两只兔子中采集骨组织，经过深冷冻处理后移植到 12 只动物的颅骨中，然后将它们随机分为两组：实验组（L）和对照组（C）。L 组的兔子接受砷化镓铝二极管激光（AlGaAs；波长 830nm，4J/cm²）照射，在颅骨的四个部位应用，每次总剂量为 16J/cm²。八次治疗后的总治疗剂量为 128J/cm²。术后 35 天（n=6）或 70 天（n=6）处死动物。

结果

深冷冻处理的块状同种异体移植物加 LLLT 后，在移植物-宿主界面处有植入物，骨改建适度，部分骨细胞陷窝填充，术后早期炎症浸润较少，胶原沉积较高。

结论

光镜和扫描电镜显示，经深冷冻加 LLLT 处理的同种异体骨可作为治疗骨缺损的替代物。使用冷冻方法处理骨移植物可保留骨组织的结构和骨诱导特性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ad/3498750/cc13b5fa36af/ijmsv09p0853g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ad/3498750/ee17cd878d4b/ijmsv09p0853g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ad/3498750/7b74bdc4e601/ijmsv09p0853g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ad/3498750/d9e1f7cd5313/ijmsv09p0853g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ad/3498750/f009c71aff83/ijmsv09p0853g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ad/3498750/cc13b5fa36af/ijmsv09p0853g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ad/3498750/ee17cd878d4b/ijmsv09p0853g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ad/3498750/7b74bdc4e601/ijmsv09p0853g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ad/3498750/d9e1f7cd5313/ijmsv09p0853g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ad/3498750/f009c71aff83/ijmsv09p0853g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ad/3498750/cc13b5fa36af/ijmsv09p0853g05.jpg

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