Li Quanmin, Zhang Zhifang, Du Ruiqin, Hu Xiaoqiang, Yan Yan, Gao Qing, Fan Yanting
Department of Endocrinology, General Hospital of the Second Artillery Force, The People's Liberation Army, No.16 Xinwai street, Xicheng District, Beijing 100088, People's Republic of China.
J Pediatr Endocrinol Metab. 2012;25(7-8):711-6. doi: 10.1515/jpem-2012-0159.
To investigate the relationship between soluble intercellular adhesion molecule (sICAM-1), vascular endothelial cell adhesion molecule (VCAM-1), monocytes chemotactic protein (MCP-1), von Willebrand factor (vWF), and coronary artery stenoses degree in coronary heart disease (CHD) within type 2 diabetes mellitus (T2DM) patients.
A total of 92 subjects were treated with coronary angiography (CAG), including 62 subjects with CHD. The individuals were divided into three groups, group A (32 patients with CHD and T2DM), group B (30 patients with CHD but no T2DM) and group C (30 patients with no CHD and T2DM). All patients were treated with a Gensini coronary angiography check. The correlations between sICAM-1, VCAM-1, MCP-1 and vWF in peripheral blood and coronary artery stenosis degree were analyzed.
The average score of coronary artery stenosis degree was 30.75 +/-12.67 in group A, which was significantly higher than group B (11.20 +/-7.51) and group C (2.40 +/- 1.23) (p < 0.01). The mean levels of sICAM-1, VCAM-1, MCP-1 and vWF in serum showed that group A was significantly higher than group B and group C (p < 0.01), and also that group B was higher than group C. There were significant positive correlations between the degree of coronary artery stenosis and the mean level of sICAM-1, VCAM-1, MCP-1, vWF in group A (p < 0.01), but these were not shown in group B and group C (p > 0.05).
Association analysis shown that the level of sICAM-1, VCAM-1, MCP-1 and vWF elevated in CHD with T2DM patients. Vascular endothelial dysfunction could be caused to the coronary artery stenosis pathophysiological process. Results from this study suggested that sICAM-1, VCAM-1, MCP-1 and vWF may contribute to the occurrence and development of vascular lesions in T2DM. These endothelial function related factors could be acceptable as a prediction and testing index of vascular complications in T2DM.
探讨2型糖尿病（T2DM）患者冠心病（CHD）中可溶性细胞间黏附分子（sICAM-1）、血管内皮细胞黏附分子（VCAM-1）、单核细胞趋化蛋白（MCP-1）、血管性血友病因子（vWF）与冠状动脉狭窄程度之间的关系。
对92例受试者进行冠状动脉造影（CAG）检查，其中CHD患者62例。将研究对象分为三组，A组（32例CHD合并T2DM患者）、B组（30例CHD但无T2DM患者）和C组（30例无CHD和T2DM患者）。所有患者均接受Gensini冠状动脉造影检查。分析外周血中sICAM-1、VCAM-1、MCP-1和vWF与冠状动脉狭窄程度之间的相关性。
A组冠状动脉狭窄程度平均评分为30.75±12.67，显著高于B组（11.20±7.51）和C组（2.40±1.23）（p<0.01）。血清中sICAM-1、VCAM-1、MCP-1和vWF的平均水平显示，A组显著高于B组和C组（p<0.01），且B组高于C组。A组冠状动脉狭窄程度与sICAM-1、VCAM-1、MCP-1、vWF的平均水平之间存在显著正相关（p<0.01），但B组和C组未显示出这种相关性（p>0.05）。
关联分析表明，CHD合并T2DM患者中sICAM-1、VCAM-1、MCP-1和vWF水平升高。血管内皮功能障碍可能导致冠状动脉狭窄的病理生理过程。本研究结果提示，sICAM-1、VCAM-1、MCP-1和vWF可能参与T2DM血管病变的发生和发展。这些内皮功能相关因子可作为T2DM血管并发症的预测和检测指标。
