Melis Marcello, Di Giosia Massimiliano, Zawawi Khalid H
Craniomandibular Pain Center at Tufts University, USA.
Cranio. 2012 Oct;30(4):304-12. doi: 10.1179/crn.2012.045.
The authors performed a review of the literature to evaluate the efficacy of low level laser therapy (LLLT) for the treatment of temporomandibular disorders (TMD). Selection criteria included: 1) human subjects, 2) articles written in English, and 3) randomized placebo-controlled trials. Evaluation was performed according to the CONSORT 2010 criteria. A total of 14 articles were included in the review. Studies varied considerably in terms of methodological design, particularly regarding the site of application of the laser beam, the number of applications performed, their duration, the laser beam features (wavelength, frequency, output, dosage), and outcome measures. The outcome of the trials was controversial and not particularly related to any features of the laser beam, to the number of laser applications, and their duration. Based on the results of this review no definitive conclusions can be drawn on the efficacy of LLLT for the treatment of TMD. Many methodological differences among the studies, especially regarding the number and duration of laser applications and characteristics of the laser beam (wavelength, frequency, output), do not allow for standardized guidelines for effective treatment with LLLT. The only indication seems to be that LLLT is probably more effective for the treatment of TMJ disorders, and less effective for the treatment of masticatory muscle disorders.
作者对文献进行了综述，以评估低强度激光疗法（LLLT）治疗颞下颌关节紊乱病（TMD）的疗效。选择标准包括：1）人类受试者；2）英文撰写的文章；3）随机安慰剂对照试验。根据CONSORT 2010标准进行评估。该综述共纳入14篇文章。研究在方法设计方面差异很大，特别是在激光束的应用部位、应用次数、持续时间、激光束特征（波长、频率、输出、剂量）以及结局指标方面。试验结果存在争议，且与激光束的任何特征、激光应用次数及其持续时间均无特别关联。基于该综述结果，无法就LLLT治疗TMD的疗效得出明确结论。研究之间存在许多方法学差异，尤其是在激光应用次数和持续时间以及激光束特征（波长、频率、输出）方面，这使得无法制定LLLT有效治疗的标准化指南。唯一的迹象似乎是，LLLT可能对颞下颌关节紊乱病的治疗更有效，而对咀嚼肌紊乱的治疗效果较差。
