Bach Institute of Biochemistry, Russian Academy of Sciences, 119071 Moscow, Russia.
Biochemistry (Mosc). 2012 Oct;77(10):1129-38. doi: 10.1134/S0006297912100057.
Octaheme oxidoreductases are widespread among various bacterial taxa involved in the biogeochemical nitrogen cycle. The evolution of octaheme oxidoreductases of the nitrogen cycle from the evolutionarily more ancient pentaheme nitrite reductases was accompanied by changes in function from reduction of nitrogen oxides to their oxidation under changing environmental conditions. Octaheme nitrite reductases, which are the subject of the present review, are of a transitional form that combines structural and functional characteristics of pentaheme reductases and octaheme oxidases and possesses a number of unique features typical of only this family of enzymes. The review summarizes data on structure-function investigations of the family of octaheme nitrite reductases. Emphasis is given to comparison of the structures and functions of octaheme nitrite reductases and other multiheme oxidoreductases of the nitrogen cycle.
八血红素氧化还原酶广泛存在于参与生物地球化学氮循环的各种细菌分类群中。氮循环的八血红素氧化还原酶是从进化上更古老的五血红素亚硝酸盐还原酶进化而来的，伴随着功能的变化，从还原氮氧化物到在不断变化的环境条件下氧化它们。八血红素亚硝酸盐还原酶是本综述的主题，它是一种过渡形式，结合了五血红素还原酶和八血红素氧化酶的结构和功能特征，并具有许多仅属于该酶家族的独特特征。该综述总结了关于八血红素亚硝酸盐还原酶家族的结构-功能研究的数据。重点比较了八血红素亚硝酸盐还原酶和其他氮循环多血红素氧化还原酶的结构和功能。
