Leffler P, Jin T Y, Nordberg G F
Department of Environmental Medicine, Umea University, Sweden.
Toxicol Appl Pharmacol. 1990 Mar 15;103(1):180-4. doi: 10.1016/0041-008x(90)90274-x.
Urinary excretion of the major minerals, calcium (Ca), magnesium (Mg), sodium (Na), and potassium (K), as well as of protein and metallothionein, was studied following the injection of cadmium-metallothionein (CdMT) in rats. Animals were given vehicle (saline) and 0.4 and 0.8 mg Cd/kg body wt as CdMT. A marked, relatively early, and reversible increase in Mg excretion was seen. The increase was dose-related, indicating a close connection to the typical Cd-derived cellular damage in the renal tubular epithelium, including an early reversible Ca excretion and a late reversible protein excretion. The increase in Mg excretion was similar in magnitude to the one for Ca and much more prominent than that recorded for Na and K. The appearance of Mg and Ca excretion peaks at an early stage after CdMT injection makes it likely that this effect is an early event in the process of development of cellular damage and does not merely represent unspecific cellular damage giving rise to proteinuria.
在给大鼠注射镉金属硫蛋白（CdMT）后，研究了主要矿物质钙（Ca）、镁（Mg）、钠（Na）和钾（K）以及蛋白质和金属硫蛋白的尿排泄情况。给动物注射载体（生理盐水）以及以CdMT形式给予0.4和0.8 mg Cd/kg体重。观察到镁排泄量有显著、相对较早且可逆的增加。这种增加与剂量相关，表明与肾小管上皮中典型的镉源性细胞损伤密切相关，包括早期可逆的钙排泄和晚期可逆的蛋白质排泄。镁排泄量的增加幅度与钙相似，比钠和钾的增加更为显著。在注射CdMT后早期出现镁和钙排泄峰值，这使得这种效应很可能是细胞损伤发展过程中的早期事件，而不仅仅代表导致蛋白尿的非特异性细胞损伤。
