荟萃分析：肿瘤坏死因子-α基因多态性与原发性胆汁性肝硬化易感性之间的关系

Meta-analysis: the relationship between TNF-alpha polymorphisms and susceptibility to primary biliary cirrhosis.

作者信息

Chen Ruirui, Cai Xiqiang, Han Zheyi, Shi Yongquan, Zhou Xinmin, Han Ying, Fan Daiming

机构信息

Xijing Hospital of Digestive Diseases, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi'an, China.

出版信息

Hepatogastroenterology. 2013 May;60(123):568-76. doi: 10.5754/hge12762.

DOI:10.5754/hge12762

PMID:23159355

Abstract

BACKGROUND/AIMS: To investigate the possible influence of TNF-α gene promoter polymorphisms in conferring a predisposition to PBC patients.

METHODOLOGY

We performed a meta-analysis of nine articles searched from PubMed up to July 2010 that investigated the association between two TNF-α polymorphisms (-308 and -238) and PBC.

RESULTS

The data showed no significant association between TNF-α-308, -238 gene polymorphisms and the susceptibility to PBC in the global group (OR=0.95, 95%CI=0.80-1.13, p=0.55; OR=1.00, 95%CI=0.65-1.55, p=0.99, respectively). Stratified by sub-groups (European, American, Asian), TNF -308 minor allele, but not -238, was found to be a protective factor in the European population (OR= 0.81, 95%CI=0.67-0.99, p=0.04; OR=0.99, 95%CI=0.55-1.77, p=0.97, respectively). Moreover, no significant difference was observed between TNF-α-308 alleles and PBC when stratified by histological stages (stages I-II, OR=0.68, 95%CI=0.32-1.48, p=0.33; stages III-IV, OR=0.69, 95%CI=0.41-1.15, p=0.15).

CONCLUSIONS

TNF-α promoter polymorphisms might not be associated with PBC risk. However, studies with larger population of varying ethnicity and stratified by clinical and laboratory characteristics are needed to validate our findings.

摘要

背景/目的：研究肿瘤坏死因子-α（TNF-α）基因启动子多态性对原发性胆汁性肝硬化（PBC）患者易感性的可能影响。

方法

我们对截至2010年7月从PubMed检索到的9篇研究TNF-α两个多态性位点（-308和-238）与PBC关联的文章进行了荟萃分析。

结果

数据显示，在总体人群中，TNF-α -308、-238基因多态性与PBC易感性之间无显著关联（OR = 0.95，95%CI = 0.80 - 1.13，p = 0.55；OR = 1.00，95%CI = 0.65 - 1.55，p = 0.99）。按亚组（欧洲、美国、亚洲）分层分析发现，在欧洲人群中，TNF -308次要等位基因是一个保护因素，而-238不是（OR分别为0.81，95%CI = 0.67 - 0.99，p = 0.04；OR = 0.99，95%CI = 0.55 - 1.77，p = 0.97）。此外，按组织学分期分层时，TNF-α -308等位基因与PBC之间未观察到显著差异（I-II期，OR = 0.68，95%CI = 0.32 - 1.48，p = 0.33；III-IV期，OR = 0.69，95%CI = 0.41 - 1.15，p = 0.15）。