Department of Neuroscience and Behavioral Science, Ribeirão Preto School of Medicine, University of São Paulo, Brazil.
Epilepsy Behav. 2012 Dec;25(4):593-7. doi: 10.1016/j.yebeh.2012.09.026. Epub 2012 Nov 14.
We studied the prevalence and associated factors of psychiatric comorbidities in 490 patients with refractory focal epilepsy. Of these, 198 (40.4%) patients had psychiatric comorbidity. An Axis I diagnosis was made in 154 patients (31.4%) and an Axis II diagnosis (personality disorder) in another 44 (8.97%) patients. After logistic regression, positive family history of psychiatric comorbidities (O.R.=1.98; 95% CI=1.10-3.58; p=0.023), the presence of Axis II psychiatric comorbidities (O.R.=3.25; 95% CI=1.70-6.22; p<0.0001), and the epileptogenic zone located in mesial temporal lobe structures (O.R.=1.94; 95% CI=1.25-3.03; p=0.003) remained associated with Axis I psychiatric comorbidities. We concluded that a combination of clinical variables and selected structural abnormalities of the central nervous system contributes to the development of psychiatric comorbidities in patients with focal epilepsy.
我们研究了 490 例耐药局灶性癫痫患者的精神共病患病率及其相关因素。其中，198 例（40.4%）患者存在精神共病。154 例患者（31.4%）存在轴 I 诊断，44 例患者（8.97%）存在轴 II 诊断（人格障碍）。经过逻辑回归，精神共病阳性家族史（OR=1.98；95%CI=1.10-3.58；p=0.023）、存在轴 II 精神共病（OR=3.25；95%CI=1.70-6.22；p<0.0001）和致痫区位于内侧颞叶结构（OR=1.94；95%CI=1.25-3.03；p=0.003）与轴 I 精神共病相关。我们得出结论，临床变量的组合和中枢神经系统的某些结构异常有助于局灶性癫痫患者精神共病的发生。
