Nahata M C, Crist K D
College of Pharmacy, Ohio State University, Columbus 43210.
Ther Drug Monit. 1990 Mar;12(2):150-3.
Gentamicin is commonly administered by intermittent infusions using a gravity-flow or a mechanical device. The primary objective of our study was to compare the pharmacokinetic data in patients receiving gentamicin infusion by a syringe pump and a new controlled-release membrane infusion device. The membrane device consists of a drug and a fluid chamber separated by a 0.2-micron proprietary membrane; drug transfer is based on electrodiffusion across the membrane. Ten patients (mean age 50 years) received the same dose of gentamicin, separated by a 24-h interval, from two devices. Differences in serum concentrations, distribution volume, and half-life were not statistically significant. However, time for complete delivery (0.9 +/- 0.4 h for membrane device vs. 0.5 h for syringe pump) and calculated dosage requirements (10.9 +/- 6.3 vs. 9.6 +/- 5.5 mg/h) to achieve peak of 7 and trough of 1 microgram/ml were significantly different (p less than 0.05). Thus, the infusion method for gentamicin can have a significant influence on its pharmacokinetic monitoring.
庆大霉素通常采用重力流或机械设备进行间歇性输注给药。我们研究的主要目的是比较使用注射泵和新型控释膜输注装置输注庆大霉素的患者的药代动力学数据。该膜装置由一个药物腔和一个流体腔组成，中间由一个0.2微米的专利膜隔开；药物传递基于跨膜电扩散。10名患者（平均年龄50岁）从两种装置中接受相同剂量的庆大霉素，间隔24小时。血清浓度、分布容积和半衰期的差异无统计学意义。然而，达到7微克/毫升峰值和1微克/毫升谷值时的完全输注时间（膜装置为0.9±0.4小时，注射泵为0.5小时）和计算得出的剂量需求（分别为10.9±6.3和9.6±5.5毫克/小时）有显著差异（p<0.05）。因此，庆大霉素的输注方法对其药代动力学监测有显著影响。
