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长期暴露于高海拔环境下的大鼠的肾上腺皮质功能。

Adrenocortical function in rats chronically exposed to high altitude.

作者信息

Ou L C, Tenney S M

出版信息

J Appl Physiol Respir Environ Exerc Physiol. 1979 Dec;47(6):1185-7. doi: 10.1152/jappl.1979.47.6.1185.

DOI:10.1152/jappl.1979.47.6.1185
PMID:231600
Abstract

In rats exposed to a simulated altitude of 5,486 m for 3 mo, pituitary and adrenal glands hypertrophied and plasma levels of corticosterone increased more than threefold over sea-level controls. The in vitro rates of corticosterone production by the quartered adrenal gland were significantly enhanced, but the responsiveness of the adrenal gland to ACTH remained normal.

摘要

在暴露于模拟海拔5486米环境3个月的大鼠中,垂体和肾上腺肥大,血浆皮质酮水平比海平面对照组增加了三倍多。四分体肾上腺皮质酮的体外生成率显著提高,但肾上腺对促肾上腺皮质激素(ACTH)的反应性仍保持正常。

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