Shulman I A, Arndt P A, McGehee W, Garratty G
Blood Bank and Transfusion Medicine Unit, Los Angeles County-University of Southern California Medical Center.
Transfusion. 1990 Mar-Apr;30(3):263-6. doi: 10.1046/j.1537-2995.1990.30390194351.x.
Until recently, all cephalosporin-induced immune hemolytic anemias appeared to react by a "penicillin-type" drug adsorption mechanism, and hemolysis was extravascular. In 1987 and 1988, the first two cases of cephalosporin-induced immune hemolytic anemia with intravascular hemolysis associated with a so-called immune complex mechanism were reported. This report describes a case of extravascular hemolysis due to a third-generation cephalosporin, cefotaxime, which, to the authors' knowledge, is the first to show in vitro characteristics of both the drug adsorption and the so-called immune complex mechanisms.
直到最近，所有头孢菌素引起的免疫性溶血性贫血似乎都是通过“青霉素型”药物吸附机制发生反应的，溶血发生在血管外。1987年和1988年，有报道称首例两例头孢菌素引起的免疫性溶血性贫血伴有血管内溶血，与所谓的免疫复合物机制有关。本报告描述了一例由第三代头孢菌素头孢噻肟引起的血管外溶血病例，据作者所知，这是首例在体外表现出药物吸附和所谓免疫复合物机制特征的病例。
