Homan van der Heide J J, Bilo H J, Tegzess A M, Donker A J
Department of Internal Medicine, University Hospital Groningen, The Netherlands.
Transplantation. 1990 Mar;49(3):523-7. doi: 10.1097/00007890-199003000-00010.
The effect of a daily supplementation of 6 g fish oil (30% C20:5 omega-3 (EPA) and 20% C22:6 omega-3 for three months on renal function variables was investigated in a placebo-controlled (6 g corn oil, 50% C18:2 omega-6) prospective, randomized, double-blind study in stable cyclosporine-treated renal transplant recipients, at least nine months after grafting. Ten patients ingested placebo capsules and eleven patients fish oil. When measuring glomerular filtration rate and effective renal plasma flow (ERPF) before (baseline [BL]) and after 3 months of oil ingestion nothing changed in the placebo-treated group: GFR-BL = 64.5 GFR-3 months = 60 ml/min/1.73m2 (NS; median, Wilcoxon test) ERPF BL = 229.5 and ERPF-3 months = 242.5 ml/min/1.73m2 (NS). In the fish oil-treated group GFR rose by 20.3% from GFR-BL = 56 to GFR-3 months = 68 ml/min/1.73m2 and ERPF by 16.4% from ERPF-BL 218 to ERPF-3 months = 245 ml/min/1.73m2, (P less than 0.01). In the placebo-treated group mean arterial pressure and calculated total renal vascular resistance (TRVR) did not change: MAP-BL = 106 mmHg and MAP-3 months = 109 mmHg, TRVR being 20856 dyne.sec/cm5 and 19862 dyne/sec/cm5, respectively (NS). In the fish oil-treated group MAP and TRVR fell by 8.6% and 21.1%, respectively: MAP-BL = 106 mmHg and MAP-3 months = 98 mmHg (P less than 0.01), TRVR-BL = 21952 dyne/sec/cm5 and TRVR-3 months = 17087 dyne/sec/cm5 (P less than 0.01). According to these results fish oil supplementation has considerable effects on renal function and blood pressure in stable CsA-treated renal transplant recipients.
在一项安慰剂对照（6克玉米油，50% C18:2 ω-6）的前瞻性、随机、双盲研究中，对至少移植九个月后接受环孢素治疗的稳定肾移植受者，研究了每日补充6克鱼油（30% C20:5 ω-3（二十碳五烯酸，EPA）和20% C22:6 ω-3）三个月对肾功能变量的影响。十名患者服用安慰剂胶囊，十一名患者服用鱼油。在摄入油之前（基线[BL]）和三个月后测量肾小球滤过率和有效肾血浆流量（ERPF）时，安慰剂治疗组没有变化：肾小球滤过率 - 基线 = 64.5，肾小球滤过率 - 三个月 = 60毫升/分钟/1.73平方米（无显著性差异；中位数，威尔科克森检验），有效肾血浆流量 - 基线 = 229.5，有效肾血浆流量 - 三个月 = 242.5毫升/分钟/1.73平方米（无显著性差异）。在鱼油治疗组中，肾小球滤过率从肾小球滤过率 - 基线 = 56上升20.3%至肾小球滤过率 - 三个月 = 68毫升/分钟/1.73平方米，有效肾血浆流量从有效肾血浆流量 - 基线218上升16.4%至有效肾血浆流量 - 三个月 = 245毫升/分钟/1.73平方米（P < 0.01）。在安慰剂治疗组中，平均动脉压和计算得出的总肾血管阻力（TRVR）没有变化：平均动脉压 - 基线 = mmHg，平均动脉压 - 三个月 = 109 mmHg，总肾血管阻力分别为20856达因·秒/厘米⁵和19862达因/秒/厘米⁵（无显著性差异）。在鱼油治疗组中，平均动脉压和总肾血管阻力分别下降了8.6%和21.1%：平均动脉压 - 基线 = 106 mmHg，平均动脉压 - 三个月 = 98 mmHg（P < 0.01），总肾血管阻力 - 基线 = 21952达因/秒/厘米⁵，总肾血管阻力 - 三个月 = 17087达因/秒/厘米⁵（P < 0.01）。根据这些结果，补充鱼油对接受环孢素治疗的稳定肾移植受者的肾功能和血压有显著影响。
