鱼油对接受环孢素治疗的银屑病患者的肾功能有保护作用吗？

Does fish oil protect renal function in cyclosporin-treated psoriasis patients?

作者信息

Stoof T J, Korstanje M J, Bilo H J, Starink T M, Hulsmans R F, Donker A J

机构信息

Department of Dermatology, Free University Hospital, Amsterdam, The Netherlands.

出版信息

J Intern Med. 1989 Dec;226(6):437-41. doi: 10.1111/j.1365-2796.1989.tb01421.x.

DOI:10.1111/j.1365-2796.1989.tb01421.x

PMID:2489230

Abstract

In order to study the influence of fish oil on CyA-induced renal dysfunction, 13 patients with psoriasis (CyA group) received cyclosporin A (CyA) alone, and seven patients (CyA/EPA + DHA group) received a combination of cyclosporin A and fish oil (6g eicosapentaenoic acid, C20:5 omega-3, and docosahexaenoic acid, C22:6 omega-3, daily) for 3 months. The glomerular filtration rate fell by 18.0 +/- 9.6% in the CyA group compared with 8.7 +/- 6.8% in the CyA/EPA + DHA group (mean +/- SD, P less than 0.05). The effective renal plasma flow fell by 10.6 +/- 8.9% in the CyA group and did not change in the CyA/EPA + DHA group (P less than 0.05). The calculated total renal vascular resistance increased by 19.8 +/- 14.5% in the CyA group and did not change in the CyA/EPA + DHA group (P less than 0.01). The results of this pilot study suggest that fish oil can reduce CyA-associated renal dysfunction in psoriasis patients.

摘要

为研究鱼油对环孢素A（CyA）所致肾功能不全的影响，13例银屑病患者（CyA组）单独接受环孢素A（CyA）治疗，7例患者（CyA/EPA + DHA组）接受环孢素A与鱼油联合治疗（每天6克二十碳五烯酸，C20:5 ω-3，和二十二碳六烯酸，C22:6 ω-3），为期3个月。CyA组肾小球滤过率下降了18.0 +/- 9.6%，而CyA/EPA + DHA组为8.7 +/- 6.8%（均值 +/- 标准差，P < 0.05）。CyA组有效肾血浆流量下降了10.6 +/- 8.9%，而CyA/EPA + DHA组无变化（P < 0.05）。计算得出的总肾血管阻力在CyA组增加了19.8 +/- 14.5%，而CyA/EPA + DHA组无变化（P < 0.01）。这项初步研究结果表明，鱼油可减轻银屑病患者中与CyA相关的肾功能不全。