Katz A, Kerem D, Sherman D
Israeli Naval Hyperbaric Institute, Haifa.
Undersea Biomed Res. 1990 Jan;17(1):45-9.
We studied the effects of parenteral magnesium sulfate (MgSO4) administration on electroencephalographic seizures induced by hyperbaric oxygen (HBO) in awake rats. Sixteen rats chronically implanted with electrocorticographic electrodes were preinjected i.p. with either vehicle or 3 mmol/kg MgSO4 (the latter resulted in serum levels of 3.5-5.5 mmol/liter) and then exposed to 6 ATA O2 in a pressure chamber. The time to develop an electric ichtal seizure was measured and compared to that in the same animal receiving the alternate treatment 3 days later. Mean and median times after the magnesium treatment were almost double those of vehicle administration. A central anticonvulsive action of magnesium, which should be investigated over the entire HBO range, is indicated.
我们研究了腹腔注射硫酸镁（MgSO4）对清醒大鼠高压氧（HBO）诱发的脑电图癫痫发作的影响。16只长期植入皮质脑电图电极的大鼠腹腔内预先注射溶媒或3 mmol/kg MgSO4（后者导致血清水平为3.5 - 5.5 mmol/升），然后在压力舱中暴露于6个绝对大气压的氧气中。测量出现癫痫发作的时间，并与3天后接受另一种治疗的同一只动物的发作时间进行比较。镁治疗后的平均和中位数时间几乎是注射溶媒后的两倍。这表明镁具有中枢抗惊厥作用，应在整个HBO范围内进行研究。
