Bitterman N, Katz A
Aviat Space Environ Med. 1987 Mar;58(3):224-6.
The effect of sodium phenytoin on hyperbaric oxygen (HBO) induced central nervous system (CNS) toxicity was studied in rats. The latency of the epileptic electroencephalographic discharges was measured in 20 phenytoin-treated rats exposed to 6 ATA of 100% oxygen, and compared with that of 20 saline-injected rats exposed to the same pressure of pure oxygen. No statistically significant difference was found in the latency between the two groups. In addition, phenytoin failed to suppress or to modify the clinical seizures. Sodium phenytoin failed to suppress or to modify the clinical seizures. Sodium phenytoin blood levels were determined in the rats, and were found to be within the therapeutic range. We conclude that sodium phenytoin is ineffective in suppressing HBO induced CNS oxygen toxicity.
在大鼠中研究了苯妥英钠对高压氧（HBO）诱导的中枢神经系统（CNS）毒性的影响。对20只接受苯妥英钠治疗并暴露于6个绝对大气压（ATA）的100%氧气环境中的大鼠测量癫痫脑电图放电的潜伏期，并与20只注射生理盐水并暴露于相同纯氧压力环境中的大鼠进行比较。两组之间的潜伏期未发现统计学上的显著差异。此外，苯妥英钠未能抑制或改变临床癫痫发作。测定了大鼠的苯妥英钠血药浓度，发现其在治疗范围内。我们得出结论，苯妥英钠在抑制HBO诱导的CNS氧毒性方面无效。
