Department of Dermatology, Huriez Hospital, Regional and University Hospital, Lille, France.
In Vivo. 2012 Nov-Dec;26(6):1079-86.
Melanoma has the highest rate of spread to the leptomeninges and the incidence of melanoma has been steadily rising. This article describes recent experience at the Lille University Hospital, between 2007 and 2011 and discusses the possibilities for treatment of leptomeningeal metastasis.
Nine patients were diagnosed with leptomeningeal metastasis of melanoma. The standard criteria were used for the diagnosis. The treatment consisted of a combination of intrathecal chemotherapy, systemic chemotherapy and best supportive care.
The overall median survival from the time of leptomeningeal metastasis diagnosis was eight weeks (range=1-168 weeks). In two cases, the median overall survival was 104 weeks. For these patients, there was a clear benefit in intrathecal chemotherapy combined with systemic treatment. No complication was observed.
Despite a poor prognosis, treatment of melanoma leptomeningeal metastasis is needed in order to improve the quality of life, neurological progression-free survival and overall survival of patients.
黑色素瘤向软脑膜转移的发生率最高，且黑色素瘤的发病率一直在稳步上升。本文描述了里尔大学医院 2007 年至 2011 年间的近期经验，并讨论了治疗软脑膜转移的可能性。
9 名患者被诊断为黑色素瘤软脑膜转移。诊断采用标准标准。治疗包括鞘内化疗、全身化疗和最佳支持治疗。
从软脑膜转移诊断时间开始的总体中位生存时间为 8 周（范围为 1-168 周）。在 2 例中，中位总生存期为 104 周。对于这些患者，鞘内化疗联合全身治疗有明显的益处。未观察到并发症。
尽管预后不良，但为了提高患者的生活质量、无神经进展生存期和总生存期，需要治疗黑色素瘤软脑膜转移。
