体外冲击波碎石术后血细胞及生化变化

Blood cellular and biochemical changes after extracorporeal shock wave lithotripsy.

作者信息

Di Silverio F, Gallucci M, Gambardella P, Alpi G, Benedetti R, La Mancusa R, Pulcinelli F M, Romiti R, Gazzaniga P P

机构信息

Urological Pathology, University of Rome, La Sapienza, Italy.

出版信息

Urol Res. 1990;18(1):49-51. doi: 10.1007/BF00294583.

DOI:10.1007/BF00294583

PMID:2316072

Abstract

The present study deals with blood cell behaviour and related hematochemical changes occurring in man after exposure to extracorporeal shock wave lithotripsy (ESWL). The following parameters have been investigated, before and after treatment, in a longitudinal study carried out on 58 patients of our Center: RBC count, Ht, Blood Hb, Plasma Hb, autohemolysis after 72 hours, bilirubinemia, WBC count, platelet count, in vitro platelet aggregation, beta-TG, sideremia and urinary post-exposure transferrin concentration. After exposure to ESWL, with pulse numbers ranging from 350 to 3,000, 18-20 KV, direct and indirect evidences of hemolysis have been found when number of SW exceeded 1,000. The hemolysis rate in different models of in vitro exposure to ESWL of blood samples was also investigated. Increase of WBC count, and changes of the platelet in vitro aggregation patterns were also observed. Changes in sideremia values have been related to urinary loss of transferrin.

摘要

本研究探讨了人体在接受体外冲击波碎石术（ESWL）后血细胞行为及相关血液生化变化。在本中心对58例患者进行的一项纵向研究中，于治疗前后对以下参数进行了调查：红细胞计数、血细胞比容、血红蛋白、血浆血红蛋白、72小时后自身溶血、胆红素血症、白细胞计数、血小板计数、体外血小板聚集、β-血小板球蛋白、血清铁及暴露后尿转铁蛋白浓度。在接受ESWL治疗后，冲击波数量在350至3000之间，电压为18 - 20千伏，当冲击波数量超过1000时，发现了溶血的直接和间接证据。还研究了不同体外ESWL暴露模型下血样的溶血率。观察到白细胞计数增加以及体外血小板聚集模式的变化。血清铁值的变化与转铁蛋白的尿流失有关。