Iyer Subramania, Balasubramanian Deepak
Department of Plastic and Reconstructive Surgery, Amrita Institute of Medical Sciences, Kochi, Kerala, India ; Department of Head and Neck Surgery, Amrita Institute of Medical Sciences, Kochi, Kerala, India.
Indian J Plast Surg. 2012 May;45(2):325-31. doi: 10.4103/0970-0358.101311.
Radiotherapy forms an integral part in cancer treatment today. It is used alone or in combination with surgery and chemotherapy. Although radiotherapy is useful to effect tumour death, it also exerts a deleterious effect on surrounding normal tissues. These effects are either acute or can manifest months or years after the treatment. The chronic wounds are a result of impaired wound healing. This impairment results in fibrosis, nonhealing ulcers, lymphoedema and radionecrosis amongst others. This article will discuss the pathophysiology in brief, along with the manifestations of radiation-induced injury and the treatment available currently.
放射治疗在当今癌症治疗中是不可或缺的一部分。它可单独使用,也可与手术和化疗联合使用。尽管放射治疗有助于实现肿瘤死亡,但它也会对周围正常组织产生有害影响。这些影响要么是急性的,要么会在治疗数月或数年后显现出来。慢性伤口是伤口愈合受损的结果。这种损伤会导致纤维化、不愈合溃疡、淋巴水肿和放射性坏死等。本文将简要讨论其病理生理学,以及辐射诱导损伤的表现和目前可用的治疗方法。