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[利用甘草化合物数据库对甘草中成分进行分类与分布分析]

[Classification and distribution analysis of components in Glycyrrhiza using licorice compounds database].

作者信息

Xiang Cheng, Qiao Xue, Ye Min, Guo De-an

机构信息

The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.

出版信息

Yao Xue Xue Bao. 2012 Aug;47(8):1023-30.

Abstract

In order to study the chemical components of licorice deeply and systematically, a licorice compounds database was established after the comprehensive summary of the compounds in Glycyrrhiza. The database was used to classify the licorice components anew in order to statistically analyze the distribution of each type of compounds and the compounds in the medical Glycyrrhiza plants. The results indicated that 422 compounds had been reported in Glycyrrhiza so far, and they could be categorized into 5 classes as flavoids, coumarins, triterpenoids, stilbenoids, and some others. Up to now, 170 compounds were isolated from G. uralensis, 134 compounds from G. glabra, 52 compunds from G. inflata, and 31 from G. yunnanensis. It is the first time to add categorization "stilbenoids", and "dibenzoylmethanes" classified as chalcones. In the meantime, the database is supposed to be convenient for further study.

摘要

为了深入系统地研究甘草的化学成分,在全面总结甘草属植物中的化合物后,建立了一个甘草化合物数据库。该数据库用于对甘草成分进行重新分类,以便对各类化合物以及药用甘草属植物中的化合物分布进行统计分析。结果表明,目前已报道甘草属植物中有422种化合物,它们可分为5类,即黄酮类、香豆素类、三萜类、芪类和其他一些类。截至目前,从乌拉尔甘草中分离出170种化合物,光果甘草中分离出134种化合物,胀果甘草中分离出52种化合物,云南甘草中分离出31种化合物。首次增加了“芪类”分类,以及归类为查耳酮的“二苯甲酰甲烷”。同时,该数据库将便于进一步研究。

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