Department of Bacterial Genetics, Institute of Microbiology, Faculty of Biology, University of Warsaw, Warsaw, Poland.
Pol J Microbiol. 2012;61(2):95-104.
Due to the alarming spread of resistance to classic antimicrobial agents, innovative therapeutic methods to combat antibiotic-resistant bacterial pathogens are urgently required. This minireview examines the enhancement of antibiotic efficacy by their combination with new antimicrobials, such as plant-derived compounds, metal ions and nanoparticles and bacteriophage lytic enzymes. The mechanisms of the observed synergy are also described. The promising results of basic research indicate that in future, combined therapy may be applied in human and veterinary medicine, agriculture and the food industry to combat bacterial pathogens.
由于对抗经典抗菌剂的耐药性令人震惊地蔓延，因此迫切需要创新的治疗方法来对抗对抗生素耐药的细菌病原体。这篇小综述探讨了通过将抗生素与新的抗菌剂（如植物衍生化合物、金属离子和纳米颗粒以及噬菌体裂解酶）联合使用来增强抗生素功效的方法。还描述了观察到的协同作用的机制。基础研究的有希望的结果表明，在未来，联合疗法可能会应用于人类和兽医医学、农业和食品工业中，以对抗细菌病原体。
