Department of Ophthalmology, Shahed University, Tehran, Iran.
Ocul Immunol Inflamm. 2012 Dec;20(6):406-18. doi: 10.3109/09273948.2012.723109. Epub 2012 Nov 19.
This review represents the current in vitro, in vivo, animal and human investigations on the roles of IL-10 in ocular inflammatory conditions.
The data sources were literature reviews, including Pub Med, Medline, and ISI databases (since 1989 to mid-2012). Search items were, IL-10, chemokines, cytokines, alone or in combination with, serum, aqueous, vitreous eye, ocular, ocular tissues, ophthalmic, and review.
Ocular effects of IL-10 depend on the sources of the secretion and sites of the action. IL-10 plays important anti-inflammatory and especially anti-angiogenic activities in ocular tissues such as the conjunctiva, cornea, retina, choroid, and orbit.
IL-10 plays major anti-inflammatory and anti-angiogenic roles in most of the ocular inflammations. Also, IL-10 plays a role in development of anterior chamber-associated immune deviation (ACAID). Any manipulation of IL-10 for treatment purposes should be considered very cautiously due to its potential hazards to the immune system.
本综述代表了目前关于 IL-10 在眼部炎症性疾病中的作用的体外、体内、动物和人体研究。
数据来源是文献综述，包括 Pub Med、Medline 和 ISI 数据库（自 1989 年至 2012 年年中）。搜索项为 IL-10、趋化因子、细胞因子，单独或组合使用，血清、房水、玻璃体眼、眼部、眼部组织、眼科和综述。
IL-10 的眼部作用取决于分泌的来源和作用部位。IL-10 在结膜、角膜、视网膜、脉络膜和眼眶等眼部组织中具有重要的抗炎和特别是抗血管生成作用。
IL-10 在大多数眼部炎症中发挥主要的抗炎和抗血管生成作用。此外，IL-10 在房水相关免疫偏离（ACAID）的发展中发挥作用。由于其对免疫系统的潜在危害，任何出于治疗目的而对 IL-10 的操纵都应非常谨慎地考虑。
