Immunoregulation Research Center, Shahed University, Tehran, Iran.
Ocul Immunol Inflamm. 2011 Dec;19(6):401-12. doi: 10.3109/09273948.2011.618902.
This review presents the current in vitro and in vivo animal and human research on the roles of IL-8 in ocular inflammatory diseases.
Data sources were a literature review using Pub Med, Medline, and ISI databases (from 1990 to 2011). Search items included interleukine-8 (IL-8), CXCL8, chemokines, cytokines, alone or in combination with the, serum, aqueous, vitreous, eye, ocular, ocular tissues, ophthalmic, and review.
IL-8 may be involved in primary or secondary ocular inflammations. Ocular effects of IL-8 differ based on the source of the secretion and site of the action. The most important effects of IL-8 in the eyes are angiogenic activities and induction of ocular inflammation.
IL-8 plays important roles in ocular inflammation and angiogenesis in conjunctiva, cornea, iris, retina, and orbit. Anti-IL-8 targeted immunotherapy has been introduced as an important treatment modality, provided that IL-8 signal blocking takes place in desired areas and tissues.
本综述介绍了目前关于白细胞介素-8（IL-8）在眼部炎症性疾病中的作用的体外和体内动物及人体研究。
使用 Pub Med、Medline 和 ISI 数据库（1990 年至 2011 年）进行文献回顾。搜索项包括白细胞介素-8（IL-8）、CXCL8、趋化因子、细胞因子，单独或组合使用血清、房水、玻璃体、眼、眼部、眼部组织、眼科和综述。
IL-8 可能参与原发性或继发性眼部炎症。IL-8 在眼部的作用因分泌源和作用部位的不同而不同。IL-8 在眼部最重要的作用是血管生成活性和诱导眼部炎症。
IL-8 在结膜、角膜、虹膜、视网膜和眼眶的眼部炎症和血管生成中发挥重要作用。抗 IL-8 靶向免疫疗法已被引入作为一种重要的治疗方式，只要 IL-8 信号阻断发生在所需的区域和组织中。
