核因子-κB 在胰腺炎中的作用：多面手，但哪个更重要？
Nuclear factor-κB in pancreatitis: Jack-of-all-trades, but which one is more important?
出版信息
Gastroenterology. 2013 Jan;144(1):26-9. doi: 10.1053/j.gastro.2012.11.016. Epub 2012 Nov 16.
Abstract
See “Deletion of IκBα activates RelA to reduce acute pancreatitis in mice through up-regulation of Spi2A,” by Neuhöfer P, Liang S, Einwächter H, et al, on page 192; and “Activation of nuclear factor-κB in acinar cells increases the severity of pancreatitis in mice,” by Huang H, Liu Y, Daniluk J, et al, on page 202.
摘要
参见 Neuhöfer P、Liang S、Einwächter H 等人发表于 192 页的“通过上调 Spi2A，IκBα 的缺失激活 RelA 以减少小鼠的急性胰腺炎”，以及 Huang H、Liu Y、Daniluk J 等人发表于 202 页的“核因子-κB 在腺泡细胞中的激活增加了小鼠胰腺炎的严重程度”。
相似文献
1
Nuclear factor-κB in pancreatitis: Jack-of-all-trades, but which one is more important?核因子-κB 在胰腺炎中的作用：多面手，但哪个更重要？
Gastroenterology. 2013 Jan;144(1):26-9. doi: 10.1053/j.gastro.2012.11.016. Epub 2012 Nov 16.
2
Deletion of IκBα activates RelA to reduce acute pancreatitis in mice through up-regulation of Spi2A.IκBα 的缺失通过上调 Spi2A 激活 RelA 减少小鼠急性胰腺炎。
Gastroenterology. 2013 Jan;144(1):192-201. doi: 10.1053/j.gastro.2012.09.058. Epub 2012 Oct 3.
3
Activation of nuclear factor-κB in acinar cells increases the severity of pancreatitis in mice.核因子-κB 在腺泡细胞中的激活增加了小鼠胰腺炎的严重程度。
Gastroenterology. 2013 Jan;144(1):202-10. doi: 10.1053/j.gastro.2012.09.059. Epub 2012 Oct 3.
4
Karyopherin Alpha 2 Promotes the Inflammatory Response in Rat Pancreatic Acinar Cells Via Facilitating NF-κB Activation.核转运蛋白α2通过促进核因子κB激活来增强大鼠胰腺腺泡细胞的炎症反应。
Dig Dis Sci. 2016 Mar;61(3):747-57. doi: 10.1007/s10620-015-3948-6. Epub 2015 Nov 2.
5
Nuclear IKKbeta is an adaptor protein for IkappaBalpha ubiquitination and degradation in UV-induced NF-kappaB activation.核 IKKβ是一种衔接蛋白，在 UV 诱导的 NF-κB 激活中，它能够促进 IkappaBα的泛素化和降解。
Mol Cell. 2010 Aug 27;39(4):570-82. doi: 10.1016/j.molcel.2010.07.030.
6
NIK and IKKbeta interdependence in NF-kappaB signalling--flux analysis of regulation through metabolites.NF-κB信号通路中NIK与IKKβ的相互依存关系——通过代谢物进行调控的通量分析
Biosystems. 2010 Feb;99(2):140-9. doi: 10.1016/j.biosystems.2009.10.009. Epub 2009 Nov 10.
7
Suppression of interleukin-6 production in macrophages by furonaphthoquinone NFD-37.呋喃萘醌NFD-37对巨噬细胞中白细胞介素-6产生的抑制作用。
Int Immunopharmacol. 2006 Jun;6(6):916-23. doi: 10.1016/j.intimp.2006.01.006. Epub 2006 Feb 3.
8
ERβ regulation of NF-kB activation in prostate cancer is mediated by HIF-1.雌激素受体β（ERβ）对前列腺癌中核因子κB（NF-κB）激活的调控是由缺氧诱导因子-1（HIF-1）介导的。
Oncotarget. 2015 Nov 24;6(37):40247-54. doi: 10.18632/oncotarget.5377.
9
BCL3 Reduces the Sterile Inflammatory Response in Pancreatic and Biliary Tissues.BCL3 降低胰腺和胆道组织中的无菌性炎症反应。
Gastroenterology. 2016 Feb;150(2):499-512.e20. doi: 10.1053/j.gastro.2015.10.017. Epub 2015 Oct 23.
10
Neuroadaptations in human chronic alcoholics: dysregulation of the NF-kappaB system.人类慢性酒精中毒者的神经适应性：核因子κB系统的失调
PLoS One. 2007 Sep 26;2(9):e930. doi: 10.1371/journal.pone.0000930.
引用本文的文献
1
Predictive Value of Serum , and Gene Expression in Acute Pancreatitis Outcomes.血清、[具体物质]及基因表达在急性胰腺炎预后中的预测价值 。（原文中“，and ”表述不完整，推测是有遗漏信息）
Diagnostics (Basel). 2025 Aug 26;15(17):2160. doi: 10.3390/diagnostics15172160.
2
Oxidative stress, DAMPs, and immune cells in acute pancreatitis: molecular mechanisms and therapeutic prospects.急性胰腺炎中的氧化应激、损伤相关分子模式和免疫细胞：分子机制与治疗前景
Front Immunol. 2025 Aug 20;16:1608618. doi: 10.3389/fimmu.2025.1608618. eCollection 2025.
3
Trypsin in pancreatitis: The culprit, a mediator, or epiphenomenon?胰腺炎中的胰蛋白酶：是罪魁祸首，还是中介，亦或是一种偶然现象？
World J Gastroenterol. 2024 Nov 7;30(41):4417-4438. doi: 10.3748/wjg.v30.i41.4417.
4
A non-human primate derived anti-P-selectin glycoprotein ligand-1 antibody curtails acute pancreatitis by alleviating the inflammatory responses.一种源自非人灵长类动物的抗P-选择素糖蛋白配体-1抗体通过减轻炎症反应来减轻急性胰腺炎。
Acta Pharm Sin B. 2023 Nov;13(11):4461-4476. doi: 10.1016/j.apsb.2023.07.028. Epub 2023 Jul 31.
5
New insights into the etiology, risk factors, and pathogenesis of pancreatitis in dogs: Potential impacts on clinical practice.对犬胰腺炎的病因、危险因素和发病机制的新认识：对临床实践的潜在影响。
J Vet Intern Med. 2022 May;36(3):847-864. doi: 10.1111/jvim.16437. Epub 2022 May 12.
6
NF-κB and Pancreatic Cancer; Chapter and Verse.核因子-κB与胰腺癌；来龙去脉
Cancers (Basel). 2021 Sep 7;13(18):4510. doi: 10.3390/cancers13184510.
7
PPAR-Alpha Agonist Fenofibrate Combined with Octreotide Acetate in the Treatment of Acute Hyperlipidemia Pancreatitis.过氧化物酶体增殖物激活受体α激动剂非诺贝特联合醋酸奥曲肽治疗急性高脂血症性胰腺炎
PPAR Res. 2021 Apr 20;2021:6629455. doi: 10.1155/2021/6629455. eCollection 2021.
8
Apigenin Decreases Acinar Cell Damage in Pancreatitis.柚皮素可减轻胰腺炎中的腺泡细胞损伤。
Pancreas. 2019 May/Jun;48(5):711-718. doi: 10.1097/MPA.0000000000001310.
9
Acute Pancreatitis: A Multifaceted Set of Organelle and Cellular Interactions.急性胰腺炎：一组多方面的细胞器和细胞相互作用。
Gastroenterology. 2019 May;156(7):1941-1950. doi: 10.1053/j.gastro.2018.11.082. Epub 2019 Jan 18.
10
Acinar cell injury induced by inadequate unfolded protein response in acute pancreatitis.急性胰腺炎中未折叠蛋白反应不足诱导的腺泡细胞损伤
World J Gastrointest Pathophysiol. 2018 Sep 29;9(2):37-46. doi: 10.4291/wjgp.v9.i2.37.
本文引用的文献
1
Deletion of IκBα activates RelA to reduce acute pancreatitis in mice through up-regulation of Spi2A.IκBα 的缺失通过上调 Spi2A 激活 RelA 减少小鼠急性胰腺炎。
Gastroenterology. 2013 Jan;144(1):192-201. doi: 10.1053/j.gastro.2012.09.058. Epub 2012 Oct 3.
2
Activation of nuclear factor-κB in acinar cells increases the severity of pancreatitis in mice.核因子-κB 在腺泡细胞中的激活增加了小鼠胰腺炎的严重程度。
Gastroenterology. 2013 Jan;144(1):202-10. doi: 10.1053/j.gastro.2012.09.059. Epub 2012 Oct 3.
3
Tumour necrosis factor α secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice.肿瘤坏死因子 α 的分泌会导致急性实验性胰腺炎中胰蛋白酶的激活和腺泡细胞的坏死。
Gut. 2013 Mar;62(3):430-9. doi: 10.1136/gutjnl-2011-300771. Epub 2012 Apr 5.
4
NF-κB and the link between inflammation and cancer.NF-κB 与炎症和癌症之间的联系。
Immunol Rev. 2012 Mar;246(1):379-400. doi: 10.1111/j.1600-065X.2012.01099.x.
5
Role of NF-κB in epithelial biology.NF-κB 在上皮生物学中的作用。
Immunol Rev. 2012 Mar;246(1):346-58. doi: 10.1111/j.1600-065X.2012.01109.x.
6
Dimer-specific regulatory mechanisms within the NF-κB family of transcription factors.NF-κB 转录因子家族内的二聚体特异性调节机制。
Immunol Rev. 2012 Mar;246(1):193-204. doi: 10.1111/j.1600-065X.2011.01091.x.
7
It takes two to tango: IκBs, the multifunctional partners of NF-κB.一个巴掌拍不响：IκBs，NF-κB 的多功能伙伴。
Immunol Rev. 2012 Mar;246(1):59-76. doi: 10.1111/j.1600-065X.2012.01102.x.
8
NF-κB, the first quarter-century: remarkable progress and outstanding questions.NF-κB，二十五年：显著进展与突出问题。
Genes Dev. 2012 Feb 1;26(3):203-34. doi: 10.1101/gad.183434.111.
9
Inflammasomes in health and disease.炎症小体在健康与疾病中的作用。
Nature. 2012 Jan 18;481(7381):278-86. doi: 10.1038/nature10759.
10
Intra-acinar trypsinogen activation mediates early stages of pancreatic injury but not inflammation in mice with acute pancreatitis.腺泡内胰蛋白酶原激活介导急性胰腺炎小鼠胰腺损伤的早期阶段，但不介导炎症反应。
Gastroenterology. 2011 Dec;141(6):2210-2217.e2. doi: 10.1053/j.gastro.2011.08.033. Epub 2011 Aug 27.
Zotero 插件