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Design of species- or isozyme-specific enzyme inhibitors. 3. Species and isozymic differences between mammalian and bacterial adenylate kinases in substituent tolerance in an enzyme-substrate complex.

作者信息

Hampton A, Picker D

出版信息

J Med Chem. 1979 Dec;22(12):1529-32. doi: 10.1021/jm00198a018.

DOI:10.1021/jm00198a018
PMID:231655
Abstract
摘要

相似文献

1
Design of species- or isozyme-specific enzyme inhibitors. 3. Species and isozymic differences between mammalian and bacterial adenylate kinases in substituent tolerance in an enzyme-substrate complex.物种特异性或同工酶特异性酶抑制剂的设计。3. 酶-底物复合物中哺乳动物和细菌腺苷酸激酶在取代基耐受性方面的物种及同工酶差异。
J Med Chem. 1979 Dec;22(12):1529-32. doi: 10.1021/jm00198a018.
2
Species- or isozyme-specific enzyme inhibitors. 4. Design of a two-site inhibitor of adenylate kinase with isozyme selectivity.物种或同工酶特异性酶抑制剂。4. 具有同工酶选择性的腺苷酸激酶双位点抑制剂的设计。
J Med Chem. 1982 Jun;25(6):638-44. doi: 10.1021/jm00348a006.
3
Species- or isozyme-specific enzyme inhibitors. 8. Synthesis of disubstituted two-substrate condensation products as inhibitors of rat adenylate kinases.物种或同工酶特异性酶抑制剂。8. 作为大鼠腺苷酸激酶抑制剂的二取代双底物缩合产物的合成。
J Med Chem. 1982 Oct;25(10):1179-84. doi: 10.1021/jm00352a016.
4
Use of adenine nucleotide derivatives to assess the potential of exo-active-site-directed reagents as species- or isozyme-specific enzyme inactivators. 4. Interactions of adenosine 5'-triphosphate derivatives with adenylate kinases from Escherichia coli and rat tissues.使用腺嘌呤核苷酸衍生物评估外活性位点导向试剂作为物种或同工酶特异性酶失活剂的潜力。4. 腺苷5'-三磷酸衍生物与大肠杆菌和大鼠组织中的腺苷酸激酶的相互作用。
J Med Chem. 1982 Apr;25(4):382-6. doi: 10.1021/jm00346a010.
5
Design of substrate-site-directed inhibitors of adenylate kinase and hexokinase. Effect of substrate substituents on affinity on affinity for the adenine nucleotide sites.
J Med Chem. 1976 Dec;19(12):1371-7. doi: 10.1021/jm00234a004.
6
Sulfur specifically inhibits adenylate kinase in assays for creatine kinase.在肌酸激酶检测中，硫会特异性抑制腺苷酸激酶。
Clin Chem. 1984 Sep;30(9):1555-7.
7
Synthetic inhibitors of adenylate kinases in the assays for ATPases and phosphokinases.用于ATP酶和磷酸激酶检测的腺苷酸激酶合成抑制剂。
Eur J Biochem. 1975 Sep 1;57(1):197-204. doi: 10.1111/j.1432-1033.1975.tb02291.x.
8
Studies on adenosine triphosphate transphosphorylases. XIII. Kinetic properties of the crystalline rabbit muscle ATP-AMP transphorphorylase (adenylate kinase) and a comparison with the crystalline calf muscle and liver adenylate kinases.三磷酸腺苷转磷酸酶的研究。十三。结晶兔肌ATP-AMP转磷酸酶（腺苷酸激酶）的动力学性质以及与结晶小牛肌和肝腺苷酸激酶的比较。
Arch Biochem Biophys. 1978 Oct;190(2):772-9. doi: 10.1016/0003-9861(78)90338-7.
9
Adenosine di-, tri- and tetraphosphopyridoxals modify the same lysyl residue at the ATP-binding site in adenylate kinase.
FEBS Lett. 1988 Mar 14;229(2):261-4. doi: 10.1016/0014-5793(88)81137-2.
10
Use of adenine nucleotide derivatives to assess the potential of exo-active-site-directed reagents as species- or isozyme-specific enzyme inactivators. 3. Synthesis of adenosine 5'-triphosphate derivatives with N6- or 8-substituents bearing iodoacetyl groups.
J Med Chem. 1982 Apr;25(4):373-81. doi: 10.1021/jm00346a009.