• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Species- or isozyme-specific enzyme inhibitors. 4. Design of a two-site inhibitor of adenylate kinase with isozyme selectivity.

作者信息

Hampton A, Kappler F, Picker D

出版信息

J Med Chem. 1982 Jun;25(6):638-44. doi: 10.1021/jm00348a006.

DOI:10.1021/jm00348a006
PMID:6284937
Abstract
摘要

相似文献

1
Species- or isozyme-specific enzyme inhibitors. 4. Design of a two-site inhibitor of adenylate kinase with isozyme selectivity.物种或同工酶特异性酶抑制剂。4. 具有同工酶选择性的腺苷酸激酶双位点抑制剂的设计。
J Med Chem. 1982 Jun;25(6):638-44. doi: 10.1021/jm00348a006.
2
Design of species- or isozyme-specific enzyme inhibitors. 3. Species and isozymic differences between mammalian and bacterial adenylate kinases in substituent tolerance in an enzyme-substrate complex.物种特异性或同工酶特异性酶抑制剂的设计。3. 酶-底物复合物中哺乳动物和细菌腺苷酸激酶在取代基耐受性方面的物种及同工酶差异。
J Med Chem. 1979 Dec;22(12):1529-32. doi: 10.1021/jm00198a018.
3
Sulfur specifically inhibits adenylate kinase in assays for creatine kinase.在肌酸激酶检测中，硫会特异性抑制腺苷酸激酶。
Clin Chem. 1984 Sep;30(9):1555-7.
4
Species- or isozyme-specific enzyme inhibitors. 7. Selective effects in inhibitions of rat adenylate kinase isozymes by adenosine 5'-phosphate derivatives.物种或同工酶特异性酶抑制剂。7. 5'-磷酸腺苷衍生物对大鼠腺苷酸激酶同工酶抑制作用的选择性效应。
J Med Chem. 1982 Jul;25(7):806-12. doi: 10.1021/jm00349a008.
5
Species- or isozyme-specific enzyme inhibitors. 8. Synthesis of disubstituted two-substrate condensation products as inhibitors of rat adenylate kinases.物种或同工酶特异性酶抑制剂。8. 作为大鼠腺苷酸激酶抑制剂的二取代双底物缩合产物的合成。
J Med Chem. 1982 Oct;25(10):1179-84. doi: 10.1021/jm00352a016.
6
Use of adenine nucleotide derivatives to assess the potential of exo-active-site-directed reagents as species- or isozyme-specific enzyme inactivators. 4. Interactions of adenosine 5'-triphosphate derivatives with adenylate kinases from Escherichia coli and rat tissues.使用腺嘌呤核苷酸衍生物评估外活性位点导向试剂作为物种或同工酶特异性酶失活剂的潜力。4. 腺苷5'-三磷酸衍生物与大肠杆菌和大鼠组织中的腺苷酸激酶的相互作用。
J Med Chem. 1982 Apr;25(4):382-6. doi: 10.1021/jm00346a010.
7
Elemental sulfur: a novel inhibitor of adenylate kinase.元素硫：一种新型的腺苷酸激酶抑制剂。
Biochem Biophys Res Commun. 1983 May 31;113(1):348-52. doi: 10.1016/0006-291x(83)90472-2.
8
Design of substrate-site-directed inhibitors of adenylate kinase and hexokinase. Effect of substrate substituents on affinity on affinity for the adenine nucleotide sites.
J Med Chem. 1976 Dec;19(12):1371-7. doi: 10.1021/jm00234a004.
9
Use of adenine nucleotide derivatives to assess the potential of exo-active-site-directed reagents as species- or isozyme-specific enzyme inactivators. 3. Synthesis of adenosine 5'-triphosphate derivatives with N6- or 8-substituents bearing iodoacetyl groups.
J Med Chem. 1982 Apr;25(4):373-81. doi: 10.1021/jm00346a009.
10
Adenylate kinase in human tissue. I. Organ specificity of adenylate kinase isoenzymes.人体组织中的腺苷酸激酶。I. 腺苷酸激酶同工酶的器官特异性
J Biol Chem. 1974 Mar 25;249(6):1874-9.

引用本文的文献

1
Beyond Triphosphates: Reagents and Methods for Chemical Oligophosphorylation.超越三磷酸酯：化学寡磷酰化的试剂和方法。
J Am Chem Soc. 2022 May 4;144(17):7517-7530. doi: 10.1021/jacs.1c07990. Epub 2022 Apr 26.
2
Synthetic Strategies for Dinucleotides Synthesis.二核苷酸的合成策略。
Molecules. 2019 Nov 27;24(23):4334. doi: 10.3390/molecules24234334.
3
Proceedings of the 35th annual meeting of the Deutsche Gesellschaft für Neurochirurgie in Hannover, June 13-16, 1984.1984年6月13日至16日在汉诺威举行的德国神经外科学会第35届年会会议记录
Acta Neurochir (Wien). 1984;72(1-2):111-48. doi: 10.1007/BF01406818.