He Dingwen, Yin Ming, Luo Yuanyi, Wei Qiangqiang
No.1 Department of Orthopaedics, Second Affiliated Hospital of Nanchang University, Nanchang Jiangxi 330006, PR China.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2012 Oct;26(10):1187-90.
To summarize the recent development on chondroprotective effect of alendronate (ALN) on articular cartilage in osteoarthritis (OA).
The related literature was reviewed and the main achievements in vitro/vivo studies in the fields were summarized.
ALN can improve the metabolic microenvironment of the articular cartilage in OA, inhibit subchondral bone remodeling, so it has potential protective effect on articular cartilage.
ALN is expected to become a disease-modifying OA drug in future, but OA treatment still lack a uniform basic and clinical evaluation criteria, so it has guiding significance in development and application of ALN to develope a uniform standard and obtain the clinical data.
总结阿仑膦酸盐（ALN）对骨关节炎（OA）关节软骨软骨保护作用的最新研究进展。
回顾相关文献，总结该领域体外/体内研究的主要成果。
ALN可改善OA关节软骨的代谢微环境，抑制软骨下骨重塑，因此对关节软骨具有潜在保护作用。
ALN有望在未来成为改善病情的OA药物，但OA治疗仍缺乏统一的基础和临床评估标准，因此制定统一标准并获取临床数据对ALN的研发和应用具有指导意义。
