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一名肺动脉高压地中海贫血患者接受高剂量西地那非的长期治疗。

Long-term treatment with high-dose of sildenafil in a thalassemic patient with pulmonary hypertension.

作者信息

Correale Michele, De Rosa Fiorella, Ieva Riccardo, Di Biase Matteo, Brunetti Natale Daniele

机构信息

University of Foggia, Department of Cardiology, Italy.

出版信息

Monaldi Arch Chest Dis. 2012 Jun;78(2):105-6. doi: 10.4081/monaldi.2012.131.

DOI:10.4081/monaldi.2012.131
PMID:23167153
Abstract

We report a case of a 37-years-old man, affected by thalassemia major, hypogonadotropic hypogonadism, chronic HCV-hepatitis, diabetes mellitus, severe osteoporosis, prior septic pulmonary embolism and pulmonary artery hypertension was performed a long-term treatment with high-dose of sildenafil (120 mg/die) with reduction of pulmonary arterial systolic pressure and of the dyspnea.

摘要

我们报告了一例37岁男性患者,患有重型地中海贫血、低促性腺激素性性腺功能减退、慢性丙型肝炎、糖尿病、严重骨质疏松症,既往有感染性肺栓塞和肺动脉高压,长期接受高剂量西地那非(120毫克/天)治疗,肺动脉收缩压和呼吸困难减轻。

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1
Long-term treatment with high-dose of sildenafil in a thalassemic patient with pulmonary hypertension.一名肺动脉高压地中海贫血患者接受高剂量西地那非的长期治疗。
Monaldi Arch Chest Dis. 2012 Jun;78(2):105-6. doi: 10.4081/monaldi.2012.131.
2
Long-term treatment with sildenafil in a thalassemic patient with pulmonary hypertension.
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Should we administer sildenafil to patients with obstructive pulmonary disease and pulmonary hypertension? No.我们应该给患有阻塞性肺疾病和肺动脉高压的患者使用西地那非吗?不应该。
Am J Respir Crit Care Med. 2010 Nov 1;182(9):1206; author reply 1206-7. doi: 10.1164/ajrccm.182.9.1206.
4
STARTS-2: long-term survival with oral sildenafil monotherapy in treatment-naive pediatric pulmonary arterial hypertension.STARTS-2 研究:口服西地那非单药治疗初治儿童肺动脉高压的长期生存。
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Severe pulmonary arterial hypertension in a very premature baby with bronchopulmonary dysplasia: normalization with long-term sildenafil.极早早产儿合并支气管肺发育不良致重度肺动脉高压:长期西地那非治疗后正常化。
J Cardiovasc Med (Hagerstown). 2010 Sep;11(9):704-6. doi: 10.2459/JCM.0b013e328332e745.
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A new START for Sildenafil in pediatric pulmonary hypertension: reframing the dose-survival relationship in the STARTS-2 trial.西地那非治疗儿童肺动脉高压的新起点:重新审视STARTS-2试验中的剂量-生存关系
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Successful weaning of nitric oxide facilitated by a single dose of sildenafil in a baby with persistent pulmonary hypertension of the newborn.
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Therapeutic combination of sildenafil and iloprost in a preterm neonate with pulmonary hypertension.西地那非和伊洛前列素联合治疗患有肺动脉高压的早产儿。
Pediatr Pulmonol. 2011 Jun;46(6):617-20. doi: 10.1002/ppul.21415. Epub 2011 Mar 24.
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Ivabradine in pulmonary arterial hypertension: can we delay the need for parenteral prostanoid therapy?伊伐布雷定用于肺动脉高压:我们能否推迟肠外前列腺素治疗的需求?
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Summaries for patients. A combination treatment for pulmonary hypertension.患者摘要。肺动脉高压的联合治疗。
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引用本文的文献

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The wide spectrum of β-thalassaemia intermedia-induced pulmonary hypertension: two case reports on the possible role of specific pulmonary arterial hypertension therapy.中间型β地中海贫血所致肺动脉高压的广泛谱系:关于特定肺动脉高压治疗可能作用的两例病例报告
Pulm Circ. 2021 Jul 6;11(3):20458940211030490. doi: 10.1177/20458940211030490. eCollection 2021 Jul-Sep.
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Pulmonary hypertension associated with thalassemia syndromes.地中海贫血综合征相关的肺动脉高压
Ann N Y Acad Sci. 2016 Mar;1368(1):127-39. doi: 10.1111/nyas.13037. Epub 2016 Mar 23.
3
Pulmonary arterial hypertension in a patient with β-thalassemia intermedia and reversal with infusion epoprostenol then transition to oral calcium channel blocker therapy: review of literature.
中间型β地中海贫血患者的肺动脉高压及静脉输注依前列醇逆转后转换为口服钙通道阻滞剂治疗:文献综述
Pulm Circ. 2014 Sep;4(3):520-6. doi: 10.1086/677367.