Bjerring P, Arendt-Nielsen L
Department of Dermatology, Marselisborg Hospital, Aarhus, Denmark.
Allergy. 1990 Feb;45(2):121-5. doi: 10.1111/j.1398-9995.1990.tb00469.x.
The intention was to clarify, experimentally, some of the clinical properties of capsaicin. The modulation of histamine-induced immediate inflammatory responses following subsequent topical applications of capsaicin was studied. A gradual dose-dependent reduction of the acute inflammatory reaction was observed after daily epicutaneous application of 1% capsaicin for 6 days. The modulation suggests that the small nerve fibres responsible for the neurogenic spread of the flare gradually become less excitable. After termination of capsaicin applications the flare returned to its initial value after 9 days. The recovery phase was longer than the inhibition phase, probably due to slow repletion of neuropeptides in the cutaneous nerve endings.
目的是通过实验阐明辣椒素的一些临床特性。研究了后续局部应用辣椒素后对组胺诱导的即时炎症反应的调节作用。每天经皮应用1%辣椒素，连续6天，观察到急性炎症反应呈剂量依赖性逐渐减轻。这种调节表明，负责潮红神经源性扩散的小神经纤维兴奋性逐渐降低。停止应用辣椒素后，潮红在9天后恢复到初始值。恢复阶段比抑制阶段长，可能是由于皮肤神经末梢中神经肽的补充缓慢。
