Dhein C R, Prieur D J, Riggs M W, Potter K A, Widders P R
Department of Veterinary Clinical Medicine and Surgery, Washington State University, Pullman 99164.
Am J Vet Res. 1990 Mar;51(3):439-46.
Chronic pneumonia was investigated in a litter of young Chinese Shar Pei in which 4 of 6 dogs were affected. Serum immunoglobulin concentrations (IgA, IgG, IgM) determined by radial immunodiffusion varied over time, but were not consistently lower in affected dogs, compared with control dogs. Two dogs that died had hydrocephalus and lymphoid depletion, in addition to severe broncho-pneumonia. Evaluation of ciliary ultrastructure in 2 affected dogs revealed random orientation of adjacent respiratory tract or oviductal cilia and a greater number of microtubular disarrangements, compared with control dogs. In vivo tracheal mucociliary clearance of 99mtechnetium macroaggregated albumin was absent in 1 dog examined. The ciliary abnormalities were suspected to have resulted in an inefficient mucociliary transport system predisposing to the development of pneumonia. Further evaluation of 1 Chinese Shar Pei revealed lymphocyte mitogenesis results that were not consistently less than those of a control dog, normal total hemolytic complement values, and normal blood neutrophil chemotaxis.
对一窝中华沙皮幼犬进行了慢性肺炎调查，其中6只幼犬中有4只受到影响。通过放射免疫扩散法测定的血清免疫球蛋白浓度（IgA、IgG、IgM）随时间变化，但与对照犬相比，患病犬的这些指标并非始终较低。两只死亡的犬除了患有严重支气管肺炎外，还患有脑积水和淋巴细胞耗竭。与对照犬相比，对2只患病犬的纤毛超微结构评估显示，相邻呼吸道或输卵管纤毛的方向随机，微管排列紊乱的数量更多。在检查的1只犬中，体内99m锝标记的聚合白蛋白的气管黏液纤毛清除功能缺失。怀疑纤毛异常导致了黏液纤毛转运系统效率低下，易引发肺炎。对1只中华沙皮犬的进一步评估显示，淋巴细胞有丝分裂结果并非始终低于对照犬，总溶血补体值正常，血液中性粒细胞趋化性正常。
