Afzelius B A, Carlsten J, Karlsson S
J Am Vet Med Assoc. 1984 Mar 1;184(5):560-3.
Situs inversus, rhinitis, and bronchitis were diagnosed in a 7-month-old male Golden Retriever. Electron microscopic examination of tracheal and bronchial biopsy specimens revealed 9% of the cilia with abnormal axonemal pattern and 1.2% with a fibrous ring between the circle of microtubular doublets and the cell membrane. A permanent response to treatment with antibiotics was not obtained and the dog was euthanatized. At necropsy the thoracic and abdominal organs were found to be in reversed position. Microscopic examination revealed evidence of chronic bronchitis as well as cystic and distended distal tubules of the kidneys. Foci of fibrosis were observed in the renal cortex. The diagnosis was immotile-cilia syndrome.
一只7个月大的雄性金毛猎犬被诊断出患有内脏反位、鼻炎和支气管炎。对气管和支气管活检标本进行电子显微镜检查发现，9%的纤毛轴丝模式异常，1.2%的纤毛在微管双联体环与细胞膜之间有纤维环。抗生素治疗未获得持久疗效，该犬被安乐死。尸检时发现胸腹部器官位置颠倒。显微镜检查显示有慢性支气管炎以及肾脏远端肾小管囊性扩张的证据。在肾皮质观察到纤维化病灶。诊断为纤毛不动综合征。
