Department of Chemistry, NCCR Chemical Biology, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland.
Chem Commun (Camb). 2013 Jan 7;49(2):155-7. doi: 10.1039/c2cc37287h. Epub 2012 Nov 20.
We demonstrate the synthesis and immobilization of natural product hybrids featuring an acyl-homoserine lactone and a nitrodopamine onto biocompatible TiO(2) surfaces through an operationally simple dip-and-rinse procedure. The resulting immobilized hybrids were shown to be powerful quorum sensing (QS) activators in Pseudomonas strains acting by slow release from the surface.
我们通过一种操作简单的浸渍-冲洗程序，展示了将酰基高丝氨酸内酯和硝胺基多巴胺这两种天然产物的杂合体合成并固定到生物相容性 TiO(2)表面上的过程。结果表明，这些固定化的杂合体通过从表面缓慢释放，成为了 Pseudomonas 菌株中强有力的群体感应 (QS) 激活剂。
