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使用无载体的肽 - CpG - 寡脱氧核苷酸 - 脂质体复合物生产表位特异性抗体及其作为癌症疫苗在小鼠中的应用。

Production of epitope-specific antibodies using peptide-CpG-ODN-liposome complex without carriers and their application as a cancer vaccine in mice.

作者信息

Lee Younghee, Kwon Hyung-Joo

机构信息

Department of Biochemistry; College of Natural Sciences; Chungbuk National University, Chungbuk; Republic of Korea.

出版信息

Oncoimmunology. 2012 Oct 1;1(7):1215-1217. doi: 10.4161/onci.20404.

DOI:10.4161/onci.20404
PMID:23170285
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3494651/
Abstract

Low efficacy of peptide vaccines limits their potential application. We developed a powerful strategy to produce epitope-specific antibodies using peptides. Immunization with novel formula into mice showed target-specific prophylactic and therapeutic effects against tumors. Our strategy will be useful for rapid eiptope screening, therapeutic antibody production and cancer vaccine development.

摘要

肽疫苗的低功效限制了它们的潜在应用。我们开发了一种利用肽产生表位特异性抗体的有效策略。用新型配方免疫小鼠显示出针对肿瘤的靶向特异性预防和治疗效果。我们的策略将有助于快速进行表位筛选、治疗性抗体生产和癌症疫苗开发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41da/3494651/8da728e3b2c0/onci-1-1215-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41da/3494651/8da728e3b2c0/onci-1-1215-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41da/3494651/8da728e3b2c0/onci-1-1215-g1.jpg

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BMB Rep. 2011 Sep;44(9):607-12. doi: 10.5483/bmbrep.2011.44.9.607.
3
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BMC Immunol. 2011 May 18;12:29. doi: 10.1186/1471-2172-12-29.
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