冈比亚慢性腹泻和营养不良儿童中的幽门螺杆菌
Helicobacter pylori in Gambian children with chronic diarrhoea and malnutrition.
作者信息
Sullivan P B, Thomas J E, Wight D G, Neale G, Eastham E J, Corrah T, Lloyd-Evans N, Greenwood B M
机构信息
MRC Laboratories, Fajara, The Gambia.
出版信息
Arch Dis Child. 1990 Feb;65(2):189-91. doi: 10.1136/adc.65.2.189.
Abstract
Infection with Helicobacter pylori (formerly Campylobacter pylori) was studied by measuring antibody titres to H pylori in Gambian children. Serological evidence of infection was found in 12 of 82 (15%) infants aged less than 20 months; this increased to 62 of 135 (46%) in those aged 40-60 months. Positive serology was found in 41 of 77 (53%) infants with chronic diarrhoea and malnutrition (mean age 19 months, range 5-36) compared with 18 of 70 (26%) of age matched healthy controls and nearly a quarter (12/49, 24%) of age matched undernourished (marasmic) subjects. These data show that infection with H pylori is common in the Gambia and that in infancy this infection is associated with chronic diarrhoea and malnutrition.
摘要
通过检测冈比亚儿童针对幽门螺杆菌（原称幽门弯曲菌）的抗体滴度，对幽门螺杆菌感染情况进行了研究。在82名年龄小于20个月的婴儿中，有12名（15%）发现了感染的血清学证据；在40 - 60个月大的儿童中，这一比例增至135名中的62名（46%）。在77名患有慢性腹泻和营养不良的婴儿（平均年龄19个月，范围5 - 36个月）中，41名（53%）血清学呈阳性，而在年龄匹配的70名健康对照儿童中有18名（26%）呈阳性，在年龄匹配的营养不良（消瘦）儿童中近四分之一（12/49，24%）呈阳性。这些数据表明，幽门螺杆菌感染在冈比亚很常见，且在婴儿期这种感染与慢性腹泻和营养不良有关。
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