同种异体移植急性白血病小鼠模型的药物基因组学考虑因素。

Pharmacogenomic considerations of xenograft mouse models of acute leukemia.

机构信息

Jean-Pierre Aubert Research Center, INSERM U837, Institute for Cancer Research, 1 Place de Verdun, F-59045 Lille Cedex, France.

出版信息

Pharmacogenomics. 2012 Nov;13(15):1759-72. doi: 10.2217/pgs.12.158.

DOI:10.2217/pgs.12.158

PMID:23171339

Abstract

The use of combination chemotherapy to cure acute lymphoblastic leukemia in children and acute myeloid leukemia in adults emerged for acute myeloid leukemia in the 1960s and for acute lymphoblastic leukemia in the 1980s as a paradigm for curing any disseminated cancer. This article summarizes recent developments and considerations in the use of acute leukemia xenografts established in immunodeficient mice to elucidate the genetic and genomic basis of acute leukemia pathogenesis and treatment response.

摘要

组合化疗用于治疗儿童急性淋巴细胞白血病和成人急性髓细胞白血病，这一策略在 20 世纪 60 年代用于治疗急性髓细胞白血病，在 80 年代用于治疗急性淋巴细胞白血病，成为治愈任何播散性癌症的典范。本文总结了利用免疫缺陷小鼠建立的急性白血病异种移植模型来阐明急性白血病发病机制和治疗反应的遗传和基因组基础方面的最新进展和考虑因素。