Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif-sur-Yvette Cedex, France.
Chem Soc Rev. 2013 Feb 7;42(3):902-23. doi: 10.1039/c2cs35370a.
The aza-Diels Alder reaction has become one of the most widely used synthetic tools for the preparation of N-containing 6-membered heterocycles. Numerous important developments have been reported to render this reaction catalytic and enantioselective. This tutorial review highlights strategies and recent advances to achieve high efficiency and selectivity through the use of organocatalysts and transition metal complexes, allowing also the extension of this transformation substrate scope.
氮杂狄尔斯-阿尔德反应已成为制备含氮六元杂环的最广泛使用的合成工具之一。已经报道了许多重要的发展，使该反应具有催化和对映选择性。本综述重点介绍了通过使用有机催化剂和过渡金属配合物来实现高效率和选择性的策略和最新进展，同时也扩展了这种转化的底物范围。
