Thornton E W, Bradbury G E, Davies C
Department of Psychology, University of Liverpool, England.
Behav Neurosci. 1990 Feb;104(1):37-43. doi: 10.1037//0735-7044.104.1.37.
The effects of lesions of the habenula on responses during a forced swimming test (FST) were examined. Active behavior, documented by turns on a drum immersed in a water tank, were reduced in lesioned rats. Lesioned rats also demonstrated an inability to escape from the water by climbing onto the drum when it was locked in position at the end of the test. There was a tendency for lesioned rats to show more activity in open-field tests either after the FST or independent of such prior testing. Lesioned rats showed no motor or postural abnormalities and were able to maintain position for longer than controls during a rotating rod test. Collectively, the results are compatible with the suggestion that lesions of the habenula impair the ability to change motor strategies under stress but indicate such failures may not be ascribed to gross motor impairment.
研究了缰核损伤对强迫游泳试验（FST）期间反应的影响。通过记录浸泡在水箱中的鼓的转动来记录主动行为，损伤大鼠的主动行为减少。当鼓在试验结束时锁定在某个位置时，损伤大鼠也表现出无法通过爬上鼓来逃离水面。无论是在FST之后还是独立于这种先前测试，损伤大鼠在旷场试验中都有表现出更多活动的趋势。损伤大鼠在旋转杆试验中未表现出运动或姿势异常，并且能够比对照组保持姿势更长时间。总体而言，这些结果与以下观点一致，即缰核损伤会损害在压力下改变运动策略的能力，但表明这种失败可能不能归因于严重的运动损伤。
