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Ceramide and insulin resistance: how should the issue be approached?

作者信息

Górski Jan

机构信息

Department of Physiology, Medical University of Białystok, Białystok, Poland.

出版信息

Diabetes. 2012 Dec;61(12):3081-3. doi: 10.2337/db12-1157.

DOI:10.2337/db12-1157

PMID:23172961

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3501848/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ceff/3501848/8fe8ed8a46ed/3081fig1.jpg

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Ceramide and insulin resistance: how should the issue be approached?

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Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high-fat diet-fed mice.

Diabetes. 2012 Dec;61(12):3148-55. doi: 10.2337/db12-0029. Epub 2012 Sep 6.

MicroRNA-34a causes ceramide accumulation and effects insulin signaling pathway by targeting ceramide kinase (CERK) in aging skeletal muscle.

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CerS1-Derived C Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance.

Cell Rep. 2019 Jan 2;26(1):1-10.e7. doi: 10.1016/j.celrep.2018.12.031.

Ceramides mediate cigarette smoke-induced metabolic disruption in mice.

Am J Physiol Endocrinol Metab. 2014 Nov 15;307(10):E919-27. doi: 10.1152/ajpendo.00258.2014. Epub 2014 Sep 30.

CrossTalk opposing view: Intramyocellular ceramide accumulation does not modulate insulin resistance.

J Physiol. 2016 Jun 15;594(12):3171-4. doi: 10.1113/JP271677. Epub 2016 Mar 20.

CrossTalk proposal: Intramyocellular ceramide accumulation does modulate insulin resistance.

J Physiol. 2016 Jun 15;594(12):3167-70. doi: 10.1113/JP271676. Epub 2016 Mar 20.

Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular accumulation of lipid metabolites.

J Appl Physiol (1985). 2006 May;100(5):1467-74. doi: 10.1152/japplphysiol.01438.2005. Epub 2005 Dec 15.

Intramyocellular Ceramides: Subcellular Concentrations and Fractional De Novo Synthesis in Postabsorptive Humans.

Diabetes. 2017 Aug;66(8):2082-2091. doi: 10.2337/db17-0082. Epub 2017 May 8.

Ceramide content is increased in skeletal muscle from obese insulin-resistant humans.

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引用本文的文献

Abdominal Obesity: An Independent Influencing Factor of Visuospatial and Executive/Language Ability and the Serum Levels of A40/A42/Tau Protein.

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CerS1 but Not CerS5 Gene Silencing, Improves Insulin Sensitivity and Glucose Uptake in Skeletal Muscle.

Cells. 2022 Jan 8;11(2):206. doi: 10.3390/cells11020206.

Sulforaphane Prevents Hepatic Insulin Resistance by Blocking Serine Palmitoyltransferase 3-Mediated Ceramide Biosynthesis.

Nutrients. 2019 May 27;11(5):1185. doi: 10.3390/nu11051185.

Links Between Obesity-Induced Brain Insulin Resistance, Brain Mitochondrial Dysfunction, and Dementia.

Front Endocrinol (Lausanne). 2018 Aug 31;9:496. doi: 10.3389/fendo.2018.00496. eCollection 2018.

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Diabetologia. 2018 Dec;61(12):2570-2579. doi: 10.1007/s00125-018-4720-1. Epub 2018 Aug 29.

A peptide antagonist of Prep1-p160 interaction improves ceramide-induced insulin resistance in skeletal muscle cells.

Oncotarget. 2017 May 30;8(42):71845-71858. doi: 10.18632/oncotarget.18286. eCollection 2017 Sep 22.

Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity.

Nat Commun. 2013;4:2384. doi: 10.1038/ncomms3384.

本文引用的文献

Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high-fat diet-fed mice.

Diabetes. 2012 Dec;61(12):3148-55. doi: 10.2337/db12-0029. Epub 2012 Sep 6.

Ceramide kinase deficiency improves diet-induced obesity and insulin resistance.

FEBS Lett. 2012 May 7;586(9):1300-5. doi: 10.1016/j.febslet.2012.03.032. Epub 2012 Mar 27.

Sphingolipids: agents provocateurs in the pathogenesis of insulin resistance.

Diabetologia. 2011 Jul;54(7):1596-607. doi: 10.1007/s00125-011-2127-3. Epub 2011 Apr 6.

An overview of sphingolipid metabolism: from synthesis to breakdown.

Adv Exp Med Biol. 2010;688:1-23. doi: 10.1007/978-1-4419-6741-1_1.

Targeting ceramide synthesis to reverse insulin resistance.

Diabetes. 2010 Oct;59(10):2351-3. doi: 10.2337/db10-0912.

Effect of high fat diet enriched with unsaturated and diet rich in saturated fatty acids on sphingolipid metabolism in rat skeletal muscle.

J Cell Physiol. 2010 Nov;225(3):786-91. doi: 10.1002/jcp.22283.

Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption.

Diabetes. 2010 Oct;59(10):2453-64. doi: 10.2337/db09-1293. Epub 2010 Jun 3.

Sphingolipids and insulin resistance: the five Ws.

Curr Opin Lipidol. 2010 Apr;21(2):128-35. doi: 10.1097/MOL.0b013e3283373b66.

Glycosphingolipids and insulin resistance.

Prog Lipid Res. 2009 May-Jul;48(3-4):196-205. doi: 10.1016/j.plipres.2009.03.002. Epub 2009 Mar 20.

Bioactive sphingolipids: metabolism and function.

J Lipid Res. 2009 Apr;50 Suppl(Suppl):S91-6. doi: 10.1194/jlr.R800080-JLR200. Epub 2008 Nov 17.

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Ceramide and insulin resistance: how should the issue be approached?

作者信息

Górski Jan

机构信息

Department of Physiology, Medical University of Białystok, Białystok, Poland.

出版信息

Diabetes. 2012 Dec;61(12):3081-3. doi: 10.2337/db12-1157.

DOI:10.2337/db12-1157

PMID:23172961

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3501848/

Abstract

摘要

相似文献

Ceramide and insulin resistance: how should the issue be approached?

Diabetes. 2012 Dec;61(12):3081-3. doi: 10.2337/db12-1157.

Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high-fat diet-fed mice.

Diabetes. 2012 Dec;61(12):3148-55. doi: 10.2337/db12-0029. Epub 2012 Sep 6.

MicroRNA-34a causes ceramide accumulation and effects insulin signaling pathway by targeting ceramide kinase (CERK) in aging skeletal muscle.

J Cell Biochem. 2020 Jun;121(5-6):3070-3089. doi: 10.1002/jcb.29312. Epub 2020 Feb 14.

CerS1-Derived C Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance.

Cell Rep. 2019 Jan 2;26(1):1-10.e7. doi: 10.1016/j.celrep.2018.12.031.

Ceramides mediate cigarette smoke-induced metabolic disruption in mice.

Am J Physiol Endocrinol Metab. 2014 Nov 15;307(10):E919-27. doi: 10.1152/ajpendo.00258.2014. Epub 2014 Sep 30.

CrossTalk opposing view: Intramyocellular ceramide accumulation does not modulate insulin resistance.

J Physiol. 2016 Jun 15;594(12):3171-4. doi: 10.1113/JP271677. Epub 2016 Mar 20.

CrossTalk proposal: Intramyocellular ceramide accumulation does modulate insulin resistance.

J Physiol. 2016 Jun 15;594(12):3167-70. doi: 10.1113/JP271676. Epub 2016 Mar 20.

Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular accumulation of lipid metabolites.

J Appl Physiol (1985). 2006 May;100(5):1467-74. doi: 10.1152/japplphysiol.01438.2005. Epub 2005 Dec 15.

Intramyocellular Ceramides: Subcellular Concentrations and Fractional De Novo Synthesis in Postabsorptive Humans.

Diabetes. 2017 Aug;66(8):2082-2091. doi: 10.2337/db17-0082. Epub 2017 May 8.

Ceramide content is increased in skeletal muscle from obese insulin-resistant humans.

Diabetes. 2004 Jan;53(1):25-31. doi: 10.2337/diabetes.53.1.25.

引用本文的文献

Abdominal Obesity: An Independent Influencing Factor of Visuospatial and Executive/Language Ability and the Serum Levels of A40/A42/Tau Protein.

Dis Markers. 2022 Apr 1;2022:3622149. doi: 10.1155/2022/3622149. eCollection 2022.

CerS1 but Not CerS5 Gene Silencing, Improves Insulin Sensitivity and Glucose Uptake in Skeletal Muscle.

Cells. 2022 Jan 8;11(2):206. doi: 10.3390/cells11020206.

Sulforaphane Prevents Hepatic Insulin Resistance by Blocking Serine Palmitoyltransferase 3-Mediated Ceramide Biosynthesis.

Nutrients. 2019 May 27;11(5):1185. doi: 10.3390/nu11051185.

Links Between Obesity-Induced Brain Insulin Resistance, Brain Mitochondrial Dysfunction, and Dementia.

Front Endocrinol (Lausanne). 2018 Aug 31;9:496. doi: 10.3389/fendo.2018.00496. eCollection 2018.

Relation of plasma ceramides to visceral adiposity, insulin resistance and the development of type 2 diabetes mellitus: the Dallas Heart Study.

Diabetologia. 2018 Dec;61(12):2570-2579. doi: 10.1007/s00125-018-4720-1. Epub 2018 Aug 29.

A peptide antagonist of Prep1-p160 interaction improves ceramide-induced insulin resistance in skeletal muscle cells.

Oncotarget. 2017 May 30;8(42):71845-71858. doi: 10.18632/oncotarget.18286. eCollection 2017 Sep 22.

Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity.

Nat Commun. 2013;4:2384. doi: 10.1038/ncomms3384.

本文引用的文献

Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high-fat diet-fed mice.

Diabetes. 2012 Dec;61(12):3148-55. doi: 10.2337/db12-0029. Epub 2012 Sep 6.

Ceramide kinase deficiency improves diet-induced obesity and insulin resistance.

FEBS Lett. 2012 May 7;586(9):1300-5. doi: 10.1016/j.febslet.2012.03.032. Epub 2012 Mar 27.

Sphingolipids: agents provocateurs in the pathogenesis of insulin resistance.

Diabetologia. 2011 Jul;54(7):1596-607. doi: 10.1007/s00125-011-2127-3. Epub 2011 Apr 6.

An overview of sphingolipid metabolism: from synthesis to breakdown.

Adv Exp Med Biol. 2010;688:1-23. doi: 10.1007/978-1-4419-6741-1_1.

Targeting ceramide synthesis to reverse insulin resistance.

Diabetes. 2010 Oct;59(10):2351-3. doi: 10.2337/db10-0912.

Effect of high fat diet enriched with unsaturated and diet rich in saturated fatty acids on sphingolipid metabolism in rat skeletal muscle.

J Cell Physiol. 2010 Nov;225(3):786-91. doi: 10.1002/jcp.22283.

Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption.

Diabetes. 2010 Oct;59(10):2453-64. doi: 10.2337/db09-1293. Epub 2010 Jun 3.

Sphingolipids and insulin resistance: the five Ws.

Curr Opin Lipidol. 2010 Apr;21(2):128-35. doi: 10.1097/MOL.0b013e3283373b66.

Glycosphingolipids and insulin resistance.

Prog Lipid Res. 2009 May-Jul;48(3-4):196-205. doi: 10.1016/j.plipres.2009.03.002. Epub 2009 Mar 20.

Bioactive sphingolipids: metabolism and function.

J Lipid Res. 2009 Apr;50 Suppl(Suppl):S91-6. doi: 10.1194/jlr.R800080-JLR200. Epub 2008 Nov 17.