Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Nanchang University, Nanchang 330000, China.
The First Clinical Medical College of Nanchang University, Nanchang 330000, China.
Dis Markers. 2022 Apr 1;2022:3622149. doi: 10.1155/2022/3622149. eCollection 2022.
Although obesity affects human health and cognitive function, the influence of abdominal obesity on cognitive function is still unclear.
The MoCA scale was used to evaluate the overall cognitive function and the function of each subitem of 196 subjects, as well as the SDMT and TMT-A scales for evaluating the attention and information processing speed. In addition, radioimmunoassay was used to detect the serum levels of A40, A42, and tau protein in 45 subjects. Subjects were divided into abdominal and nonabdominal obesity groups. Before and after correcting confounding factors, the differences in cognitive scale evaluation indexes and three protein levels between the two groups were compared. We also explore further the correlation between various cognitive abilities and the waist circumference/levels of the three proteins. Linear regression was used to identify the independent influencing factors of various cognitive functions and three protein levels.
After correcting for multiple factors, we observed the lower scores of visuospatial function, execution, and language in the MoCA scale, as well as higher levels of A40 and tau protein in the abdominal obesity group, supported by the results of correlation analysis. Abdominal obesity was identified as an independent negative influencing factor of MoCA visual space, executive power, and language scores and an independent positive influencing factor of A40, A42, and tau protein levels.
Abdominal obesity may play a negative role in visuospatial, executive ability, and language function and a positive role in the A40, A42, and tau protein serum levels.
肥胖症会影响人类的健康和认知功能，而腹型肥胖对认知功能的影响仍不明确。
对 196 例受试者进行蒙特利尔认知评估量表（MoCA）评估，包括整体认知功能和各分项认知功能，以及斯特鲁普色词测验（SDMT）和连线测验 A（TMT-A）评估注意力和信息处理速度，同时采用放射免疫法检测 45 例受试者的血清 A40、A42 及 tau 蛋白水平。将受试者分为腹型肥胖组和非腹型肥胖组，在纠正混杂因素前后，比较两组认知量表评估指标和三种蛋白水平的差异，进一步探索各认知能力与腰围/三种蛋白水平的相关性。采用线性回归分析识别影响各认知功能和三种蛋白水平的独立因素。
经多因素校正后，腹型肥胖组在 MoCA 量表的视空间功能、执行功能和语言能力分项评分降低，A40 和 tau 蛋白水平升高，相关性分析结果支持这一发现。腹型肥胖是 MoCA 视空间、执行能力和语言评分的独立负性影响因素，也是 A40、A42 和 tau 蛋白水平的独立正性影响因素。
腹型肥胖可能对视觉空间、执行能力和语言功能起负性作用，对 A40、A42 和 tau 蛋白血清水平起正性作用。
