Tanaka A, Numazaki Y
Microbiol Immunol. 1979;23(9):889-97. doi: 10.1111/j.1348-0421.1979.tb02822.x.
The antigenic differences among human cytomegalovirus (CMV), two laboratory strains (Davis, AD 169), isolates from pregnant women's cervical secretions, mother's milk, infants' throat swabs and urine were analyzed by means of the plaque reduction assay using human sera which were assumed to contain monotypic antibodies by primary infection and boosted antibodies by reinfection or reactivation of the latent virus. In the cross-neutralization tests, there were no remarkable differences among the CMV strains examined. Moreover, in the neutralization kinetics, normalized kappa values among the strains constantly exceeded 80. Therefore, it is suggested that the human CMV strains examined in the study were serologically identical or very closely related.
利用假定因初次感染而含有单型抗体且因潜伏病毒再感染或再激活而含有增强抗体的人血清，通过蚀斑减少试验分析了人巨细胞病毒（CMV）、两种实验室毒株（戴维斯株、AD 169）、来自孕妇宫颈分泌物、母乳、婴儿咽拭子和尿液的分离株之间的抗原差异。在交叉中和试验中，所检测的CMV毒株之间没有显著差异。此外，在中和动力学方面，各毒株之间的标准化κ值持续超过80。因此，提示本研究中检测的人CMV毒株在血清学上相同或密切相关。
